Generation and screening of solution-phase synthetic peptide combinatorial libraries

Abstract

Following the initial use of libraries of peptides displayed on filamentous bacteriophage [1] it was inevitable that the potential of solid-phase peptide synthesis should be harnessed to produce libraries of peptides by synthetic chemical methods. These libraries made their first appearance in the mid- 1980s following the development of multiple peptide synthesis by the groups of Geysen [2], Furka [3, 4] and Houghten [5], but it was not until the early 1990s that synthetic peptide combinatorial libraries (SPCLs) were described in the literature [6–8]. This was followed by a series of papers detailing the use of peptide libraries for the discovery of novel antibacterial and antinoistic compounds [9–12] (for a review, see [13]).KeywordsSynthetic Chemical MethodMultiple Peptide SynthesisSynthetic Peptide Combinatorial LibraryFPTase InhibitorRink Amide LinkerThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.