Generating pseudo-computerized tomography (P-CT) scan images from magnetic resonance imaging (MRI) images using machine learning algorithms based on fuzzy theory for radiotherapy treatment planning.

Abstract

The substitution of computerized tomography (CT) with magnetic resonance imaging (MRI) has been investigated for external radiotherapy treatment planning. The present study aims to use pseudo-CT (P-CT) images created by MRI images to calculate the dose distribution for facilitating the treatment planning process. In this work, following image segmentation with a fuzzy clustering algorithm, an adaptive neuro-fuzzy algorithm was utilized to design the Hounsfield unit (HU) conversion model based on the features vector of MRI images. The model was generated on the set of extracted features from the gray-level co-occurrence matrices and the gray-level run-length matrices for 14 arbitrarily selected patients with brain malady. The performance of the algorithm was investigated on blind datasets through dose-volume histogram and isodose curve evaluations, using the RayPlan treatment planning system (TPS), along with the gamma analysis and statistical indices. In the proposed approach, the mean absolute error within the range of 45.4 HU was found among the test data. Also, the relative dose difference between the planning target volume region of the CT and the P-CT was 0.5%, and the best gamma pass rate for 3%/3mm was 97.2%. The proposed method provides a satisfactory average error rate for the generation of P-CT data in the different parts of the brain region from a collection of MRI series. Also, dosimetric parameters evaluation shows good agreement between reference CT and related P-CT images.