Generalized Mycobacteriosis in HIV Patients

Abstract

The objective: to evaluate clinical, laboratory and instrumental signs of generalized mycobacteriosis (MB) in HIV patients.Subjects and Methods. Generalized MB was diagnosed in 83 patients with HIV, patients. 57.8% (48 people) were men, while 42.2% (35 people) were women. The average age of patients was 39.2 years (from 19 to 63 years).Results. The M. avium complex was the main etiological agent of generalized MB in HIV patients (97.6%). The most frequent clinical manifestations included fever (80/83 (96.1%)); abdominal discomfort and pain, diarrhea (53/83 (63.8%)), and decreased body weight (56/83 (67%)). The median CD4+ count in the group was 50 cells/μL. In 52% (43/83) of cases, generalized MB developed concurrently with other opportunistic or secondary infections (CMVI, pneumocystis pneumonia, and candidiasis). In 70% of cases (55/78), NTMs were isolated from two or more biological specimens. The positive result of blood culture for NTM had the greatest clinical significance (in 32/60 (53%) of the examined patients).