General non-specific effects of balneofactors of Truskavets’ spa on parameters of neuroendocrine regulation, metabolism, immunity and microbiota in patients with chronic pyelonephritis and cholecystitis

Abstract

Background. Earlier in experiments on rats, it was shown that drinking mineral water, regardless of their mineralization and chemical composition, have similar (nonspecific) course effects on a number of parameters of metabolism and neuroendocrine-immune complex. The aim of this study is to identify such parameters in patients of Truskavets’ spa who received complex drinking balneotherapy. Materials and Methods. The object of clinical-physiological observation were 34 men aged 23-70 years, who underwent rehabilitation treatment of chronic cholecystitis and pyelonephritis in remission. The examination was performed twice, before and after a 7-10-day course of balneotherapy. All patients received bioactive water Naftussya, therewith, 11 men additionally drank sulfate-chloride sodium-magnesium water "Khrystyna" (5 g/L), and the other 11 men - water "Myroslava" with a similar chemical composition, but twice the mineralization. The object of the study were the parameters of the electroencephalogram, heart rate variability (HRV), hormones, metabolism, immunity, microbiota and cholekinetics. Results. The complex balneotherapy by interval use of Naftussya water with sulfate-chloride sodium-magnesium mineral waters causes similar significant changes in the constellation of 10 EEGs, 10 metabolic, 10 microbiota and 4 immune parameters as well as total power and entropy of HRV, calcitonin and testosterone plasma levels and cholecystokinetics activity index. Conclusion. Balneofactors of Truskavets’ spa causes non-specific modulating effects on parameters of neuroendocrine regulation, metabolism, immunity, microbiota and cholekinetics in patients with chronic pyelonephritis and cholecystitis.