Abstract

A concise, versatile, and catalytic enantioselective approach to natural and non-natural isopavine alkaloids has been developed. The synthesis takes advantage of catalytic asymmetric reaction to construct the pivotal stereogenic center in a highly enantioselective way (95-98% ee), and features use of intramolecular Pictet-Spengler reaction to build the core tetracyclic skeleton in a rapid and stereoselective fashion.

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