Abstract
Gene-Regulatory Logic to Induce and Maintain a Developmental Compartment.
Highlights
But what is the regulatory logic that combines the input of two distinct enhancers and a Polycomb Response Element (PRE) to induce the expression and maintenance of ap expression in all dorsal cells throughout development? The authors again approached this issue in a clever manner
They constructed a battery of lacZ reporter lines to decipher how these enhancers were expressed in the wing, to identify the transcription factor involved in their regulation, and to analyze the contribution of the PRE to this process
The isolated ap-E enhancer is initially expressed in all dorsal cells and responds to the early activity of the Epidermal Growth Factor (EGF)-Receptor ligand Vein, as does the whole ap locus [11]
Summary
In this issue of PLOS Genetics, Carlos Estella and colleagues [10] unravel the molecular mechanisms underlying the initiation and maintenance of ap expression in the Drosophila wing primordium. The authors functionally identified a proximal region harboring a Polycomb Response Element (PRE) and a distal fragment containing a previously identified enhancer, whose deletions severely compromised ap expression and wing development.
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