Gene Polymorphism of Platelet Glycoprotein I bα in Chinese Patients with Large- and Small-Artery Subtypes of Ischemic Stroke

Abstract

The platelet surface glycoprotein (GP) I bα, an important part of the GP I b-IX-V complex, participates in the formation of thrombosis by initially mediating platelet adhesion under high shear stress. The purpose of present study was to investigate the association between gene polymorphism of GP I bα (human platelet antigen 2, HPA2) and ischemic stroke in a matched case-control study. One hundred patients and 100 matched controls were enrolled in the study. The cases were divided into large- and small-vessel subtypes of ischemic stroke according to Trial of Org10172 in Acute Stroke Treatment criteria. Genotyping for GP I bα polymorphism was documented by polymerase chain reaction amplification and restriction enzyme analysis.There were no statistically significant differences in the GP I bα HPA2 genotype distribution between ischemic stroke group, large-vessel subtype group, small-vessel subtype group and corresponding control groups. The heterozygote genotype of GP I bα HPA2 was more frequent in the large-vessel subtype group (16.1%) than in the small-vessel subtype group (10.1%), but the difference was not statistically significant.Ourresults suggest that the polymorphism of the GP I bα HPA2 genotype might not be a genetic risk factor of ischemic stroke.