Abstract

Introduction: Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii that has been associated with infertility in women. Aims: This study investigated the relationship between miRNA146a gene polymorphisms and infertility in Iraqi females infected with toxoplasmosis. Methods: A total of 80 females aged 18-45 years were enrolled, divided into two groups: 40 infertile women with latent toxoplasmosis and 40 fertile controls. Genotyping of miRNA146a was performed using polymerase chain reaction (PCR) and sequencing. Results and Discussion: The results showed that the CC genotype of rs2910164 was associated with a higher risk of infertility and toxoplasmosis infection. Additionally, the CAAA haplotype was found to be a risk factor for infertility and toxoplasmosis, while the CAAG and GTGA haplotypes were protective against the disease. The study suggests that miRNA146a gene polymorphisms may play a crucial role in the susceptibility to toxoplasmosis infection and infertility in Iraqi females. These findings have important implications for the diagnosis and prevention of toxoplasmosis-related infertility. Conclusion: This study provides evidence for the association between specific genetic variants and susceptibility to toxoplasmosis-related infertility, contributing to our understanding of genetic risk factors in this condition

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