Abstract
We investigated the diversity of H. pylori cagPAI genes in a region at high risk of gastric cancer in the study. Thirty-five H. pylori strains were isolated from patients with gastroduodenal diseases. cagPAI genes were determined by PCR, and randomly selected amplicons were sequenced to analyze the genotypes. The results showed that 100 % of the isolates were positive for cagI, cagL, cagM, cagT and cagX. Based on the phylogenetic trees, all cagPAI genes in the isolates could be placed into two major groups (East Asian-type and Western-type), and the cagPAI genes of most isolates were included in East Asian-type. East Asian-type cagPAI genes present at a lower frequency in chronic gastritis (71.4 %) than that of gastric ulcer (100 %), duodenal ulcer (100 %), and gastric cancer (100 %) (p < 0.01). We demonstrate that East Asian-type cagPAI genes are associated with severe clinical outcomes in the region at the high risk of gastric cancer.
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