Abstract
BackgroundThe present study was conducted to assess the gender difference in the relationship between serum ferritin and 25-hydroxyvitamin D [25(OH)D] in Korean adults.MethodsA total of 5,147 adults (2,162 men, 1,563 premenopausal women, and 1,422 postmenopausal women) aged ≥ 20 years from the Korean National Health and Nutrition Examination Survey (KNHANES) data (2012) were analyzed. A covariance test adjusted for covariates was performed for serum ferritin levels in relation to vitamin D status (vitamin D deficiency, 25(OH)D < 10.0 ng/mL; vitamin D insufficiency, 25(OH)D ≥ 10.0, < 20.0 ng/mL; vitamin D sufficiency, 25(OH)D ≥ 20.0 ng/mL).ResultsThe key study results were as follows: First, in men, in terms of serum ferritin levels by serum 25(OH)D level after adjusting for age, smoking, alcohol drinking, regular exercise, SBP, DBP, WM. TC, TGs, HDL-C, FPG, Hb, Hct, MCV, and Fe, serum ferritin levels were inversely increased with the increasing of serum 25(OH)D level (P = 0.012). Second, in premenopausal women, after adjusting for related variables, serum ferritin levels were increased with the increasing of serum 25(OH)D level (P = 0.003). Third, in postmenopausal women, after adjusting for related variables, serum ferritin levels were not significantly increased with the increasing of serum 25(OH)D level (P = 0.456).ConclusionSerum 25(OH)D level was inversely associated with the serum ferritin levels in men, but was positively associated with the serum ferritin levels in premenopausal women, and was not associated with the serum ferritin levels in postmenopausal women.
Highlights
Vitamin D is involved in calcium and phosphate absorption in the intestines, whereby it maintains sufficient concentrations of circulating calcium and phosphate levels as well as normal mineralization of bone by providing the minerals to bone-forming sites [1]
total cholesterol (TC), TGs, high density lipoprotein cholesterol (HDL-C), fasting plasma glucose (FPG), Hb, Hct, mean corpuscular volume (MCV), and Fe, serum ferritin levels were inversely increased with the increasing of serum 25(OH)D level (P = 0.012)
A high serum ferritin level is associated with insulin resistance and cardiovascular disease [12,13], and a low serum ferritin level is associated with diseases such as chronic telogen effluvium and iron deficiency anemia [14,15]
Summary
The present study was conducted to assess the gender difference in the relationship between serum ferritin and 25-hydroxyvitamin D [25(OH)D] in Korean adults. Data Availability Statement: The official website of KNHANES (http://knhanes.cdc.go.kr) is currently operating an English-language information homepage. The data of the respective year are available to everyone at the free of charge. If the applicant enters simple subscription process and his email address in the official website of KNHANES, the data of the respective year can download to free of charge. If additional information is required, the readers can contact Su Yeon Park at sun4070@korea.kr
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