Abstract
In this work, ultra-small iron oxide nanoparticles were synthesized using high temperature pyrolysis. For further functionalization, dopamine was anchored onto the surface of ultra-small iron oxide nanoparticles (Fe3O4@DOPA NPs). Gd(iii) ions were chelated with diethylenetriaminepentaacetic acid (DTPA) which was linked with dopamine. The resulting Gd(iii) complex conjugated ultra-small Fe3O4 NPs [Fe3O4@DOPA(Gd-DTPA) NPs] were characterized by XRD pattern and TEM. The longitudinal relaxivity (r1) of Fe3O4@DOPA(Gd-DTPA) NPs was 9.97 mM-1 S-1. Compared to ultra-small Fe3O4 NPs and Gd(iii) complexes, Fe3O4@DOPA(Gd-DTPA) NPs showed a significant improvement of the T1-weighted MR image in aqueous solution, in vitro and in vivo.
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