Abstract
Quantitative bacterial counts were carried out on 161 gastric aspirates from 65 neonates with gastrostomies. Enterobacteriaceae, enterococci, Pseudomonas, and Candida were found far more frequently (P <00.01) than in 101 control cultures from premature infants without gastrostomies. Colonization of the sstomach was influenced by the duration of gastrostomy and the pH of gastric juice but not by systemic antibiotic therapy or type of food. Six newborns with gastrostomies developed septicemia caused by the same organisms present in elevated numbers in their gastric aspirates. The influence of non-absorbable antibiotics was studied prospectively in 72 gastric aspirates and 48 stool specimens. There was no significant difference between infants who had been treated with these antibiotics and those who had not.
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