Abstract
Although gastrointestinal (GI) tract is the most common extranodal site involved in non-Hodgkin lymphoma (NHL), primary gastrointestinal NHL (gNHL) is a rare problem which concerns about 10-15% of NHL patients and 30-40% of extranodal NHL patients. Lymphoid neoplasms may consist of mature B, T and (less commonly) extranodal NK/T cells. The most common diagnoses are diffuse large B-cell lymphoma and marginal zone lymphoma (MALT), but many other lymphomas may be found in the GI tract. There are a few well-known risk factors of gNHL and some of them affect treatment. The most frequent sites of occurrence are the stomach followed by small intestine and ileocecal region. In the last 2 decades, there has been a rapid development in the diagnosis, staging and management of GI lymphoma, but still some of such lymphomas, especially T-cell ones, are a therapeutic challenge. In this review, we present clinical and pathological features of GI lymphomas. We also describe the current status in diagnosis and treatment.
Highlights
Gastrointestinal (GI) tract is the most common extranodal site involved in non-Hodgkin lymphoma (NHL), primary gastrointestinal NHL is a rare problem which concerns about 10–15% of NHL patients and 30–40% of extranodal NHL patients
Primary gastrointestinal non-Hodgkin lymphoma, is a rare problem which concerns about 10–15% of all NHL patients and 30–40% of extranodal NHL patients.[1]
The discovery of association of H. pylori infection to gastric lymphoma led to serious approach modificatin in this disease
Summary
Gastrointestinal (GI) tract is the most common extranodal site involved in non-Hodgkin lymphoma (NHL), primary gastrointestinal NHL (gNHL) is a rare problem which concerns about 10–15% of NHL patients and 30–40% of extranodal NHL patients. Gastrointestinal (GI) tract is the most common extranodal site involved in non-Hodgkin lymphoma (NHL).
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