Abstract
An investigation of gastric secretory response following implantation of a 100 μg dose of epinephrine into various parts of the hypothalamus was undertaken in Heidenhain pouch dogs. The results indicate that the secretion of gastric pepsin increased in animals with implants in the posterior hypothalamus and median eminence. This response was blocked by pituitary stalk section and adrenalectomy. On the other hand, an intravenous injection of 100 μg/kg of epinephrine for control had no effect on gastric pepsin secretion. Thus, it seems reasonable to assume that the locally implanted epinephrine stimulates the hypothalamus, particularly the posterior hypothalamus and/or median eminence, to release adrenocorticotropic hormone, which is responsible for a typical increase in gastric pepsin secretion. This study has demonstrated the presence of a humoral mechanism in the hypothalamo-pituitary-adrenal system with regard to control of gastric secretion.
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