Abstract
Biopsy of the gastric mucosa is an integral part of a number of diagnostic and therapeutic gastroenterologic assessments. For example, biopsy of the gastric antrum followed by urease testing or histologic examination is a sensitive method to detect Helicobacter pylori. 1 Brown KE Peura DA Diagnosis of Helicobacter pylori infection. Gastroenterol Clin North Am. 1993; 22: 105-115 PubMed Google Scholar , 2 Dooley CP Cohen H Fitzgibbons PL Diagnosis of C. pylori infection based upon endoscopic techniques. in: Campylobacter pylori in gastritis and peptic ulcer disease. Igaku-Shoin, New York1989: 147-161 Google Scholar Histologic review of gastric mucosal biopsies is potentially useful in studies of other inflammatory gastric conditions and, possibly, in screening evaluations for gastric dysplasia. Gastric biopsy is also used in patients receiving long-term acid suppression with proton-pump inhibitors to quantitate gastric mucosal endocrine cell populations. 3 Solcia E Rindi G Havu N Elm G Qualitative studies of gastric endocrine cells in patients treated long-term with omeprazole. Scand J Gastroenterol. 1989; 24: 129-137 Crossref Scopus (78) Google Scholar , 4 Lamberts R Creutzfeldt W Struber HS Brunner G Solcia E Long-term omeprazole therapy in peptic ulcer disease: gastrin, endocrine cell growth, and gastritis. Gastroenterology. 1993; 104: 1356-1370 PubMed Google Scholar
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