Gastric Mucin a Prophylactic Against Gastro-Duodenal Ulcers and "Acute" Toxicity Resulting from Cincophen

Abstract

It has been shown by Van Wagoner and Churchill1 and Barbour and Fisk2 that relatively large doses of cincophen administered daily by stomach tube will cause gastro-duodenal ulcer and liver damage. The occurrence of ulcer after cincophen administration has recently been reported to occur in man.3 It has also been found that gastric mucin is prophylactic against the gastro-duodenal ulcer and disturbance of nutrition that results in some biliary fistula dogs4 and is of benefit in the nutritional disturbance that occurs in some Eck fistula (liver damage) dogs.5 Accordingly, we decided to ascertain if gastric mucin might prevent the occurrence of “peptic” ulcer in and prolong the life of dogs receiving large doses of cincophen.Twenty-eight healthy dogs were used. Fifteen served as controls in that they received only cincophen, and 13 received both cincophen and mucin. The cincophen was made up in a starch paste solution (20 gm. of cincophen, 40 gm. starch and 2000 cc. H2O), and administered by stomach tube to ...