Abstract
Abstract A gas chromatographic method is described for the determination of the monomethyl ether of diethylstilbestrol (MME) in diethylstilbestrol (DES). A 1 g sample of DES is dissolved in an aqueous solution of 0.5N sodium hydroxide and extracted with a chloroform solution containing benefin, the internal standard. The chloroform solution is back-extracted with sodium hydroxide, and an aliquot is chromatographed after silylation. The MME peaks (cis and trans') are measured relative to the internal standard peak. The method was tested for accuracy within the 120—2000 ppm range, and a linear plot of detector response vs. concentration was obtained. The method is also suitable for the determination of diethylstilbestrol dimethyl ether (DME) if present with MME in a DES sample.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
