Abstract
The median lethal doses of intravenous air and carbon dioxide were determined in 89 mongrel dogs. This study showed that air is approximately five times as toxic as carbon dioxide as an intravenous embolic agent. Blood pressure and electrocardiographic changes are described and possible mechanisms of death are discussed. The relative toxicity differential between the two gases in laboratory animals is offered as evidence for the preferential use of carbon dioxide as an insufflating or gas contrast material in clinical practice.
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