Abstract
A gas chromatographic method for the identification of 1-methylimidazole-4-acetic acid and 1-methylimidazole-5-acetic acid in urine, previously described, has been modified to allow the quantitative estimation of the 24 h excretion of the acids by man. The mean excretion of the two acids by healthy individuals was determined. The excretion of 1-methylimidazole-4-acetic acid, expressed in terms of creatinine ratios, varied within a rather narrow range (1.0–2.8 μg/mg of creatinine). It seems very likely that the estimation of this acid will give valuable information regarding the endogenous liberation and production of histamine. The daily excretion of the isomer, 1-methylimidazole-5-acetic acid was found to be very variable. The metabolic origin of this compound is discussed.
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