Abstract
We investigated the effects of garlic supplementation on triglyceride metabolism, norepinephrine secretion, and growth of interscapular brown adipose tissue in rats. Rats were fed high-fat diets with or without a garlic powder (supplemented at 0.8%) for 10 or 28 days. After 28 days of feeding, body weights and the concentrations of plasma triglycerides and free fatty acids in rats fed a diet containing garlic powder were significantly lower than in rats given no garlic powder. Interscapular brown adipose tissue weights and the mitochondrial protein were significantly greater in rats given garlic powder as compared with rats fed no garlic powder for 28 days. Furthermore, plasma concentrations and urinary excretion of norepinephrine were significantly greater in rats fed a diet containing garlic powder than in those diets without garlic powder. The in situ effects of a major volatile sulfur-containing compound (diallyldisulfide) in garlic on norepinephrine secretion were also evaluated in anesthetized animals. The norepinephrine concentration of arterial blood was significantly increased by diallyldisulfide administration, and the increase was dose-dependent. These results suggest that garlic supplementation enhances the triglyceride catabolism and growth of interscapular brown adipose tissue by increasing norepinephrine secretion in rats.
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