Abstract
Gap junctional communication in health and disease.
Highlights
Gap junctions (GJ) provide intercellular communication in all multicellular animal species, being as evolutionary distant as worm and men
The review “Gap junctions in C. elegans,” by Simonsen, Moerman, and Naus, highlights innexins, the gap junction proteins found in invertebrates
To determine the role of GJ communications (GJCs) in heart disease, they advocate for exploring the gap junction network (GJN) using large scale data mining of publicly available data sets from experimental andclinical studies (Kurtenbach et al, 2014)
Summary
Gap junctions (GJ) provide intercellular communication in all multicellular animal species, being as evolutionary distant as worm and men. Understanding biophysical properties of connexin and pannexin channels is highly relevant in the context of disease pathophysiology and drug development.
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