Abstract
Neuroendocrine tumors (NETs) are an extremely rare entity in gallbladder (GB), occurring in approximately 0.5% cases of NETs from all sites. In the present case report, a 42-year-old male presented with recurrent right upper quadrant pain for 2 months. Abdominal ultrasound revealed a small nodular swelling in the GB. On aspiration cytology that appeared as individual small tumor cells mostly in dispersed population and frequent nuclear molding within cell aggregates in a necrotic background. The patient was diagnosed as NET of GB. Histopathology revealed; uniform small rounded cells arranged in peritheliomatous pattern with intervening areas of massive necrosis. Nuclear molding, salt-pepper nuclear chromatin and frequent mitoses were also evident. Immunohistochemistry with chromogranin confirmed the diagnosis of small cell carcinoma.
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