Abstract
The objective of this study is to design a therapeutic method combining a portable high intensity focused ultrasound (HIFU) design which is suitable for the laboratory environment and a tailored integrated photo-acoustic imaging (PAI) system for monitoring thermal treatment. The electrical HIFU design is fabricated with changeable operating frequency and justified output power for resonating with different kinds of commercial transducers. The system’s control interface is built based on a touch screen to create a companionable interaction for users. The embedded fuzzy logic controller using the thermal input from the thermocouple sensor precisely drives the target temperature during HIFU exposure to achieve the expectedly coagulating results. The PAI system with 532-nm laser excitation is also integrated to define the affected region before and after HIFU treatment. The proposed fuzzy controller-integrated HIFU setup compatible with the PAI system is a feasible instrument in thermal therapy for ex vivo artificial tumors management.
Highlights
Among surgical techniques for treating solid tumors, high intensity focused ultrasound (HIFU)is a promising noninvasive approach to destroy cancerous cells [1,2]
With a typical electric HIFU framework, a low power waveform signal created by the commercial waveform generator is transmitted to the RF power amplifier which intensifies the waveform before applying it to the HIFU transducer through an impedance matching network [7,8,9,10]
This study proposes the integration of the fuzzy controller supporting the HIFU system with photo-acoustic imaging (PAI)
Summary
Among surgical techniques for treating solid tumors, high intensity focused ultrasound (HIFU)is a promising noninvasive approach to destroy cancerous cells [1,2]. The high-power ultrasound waves generated from the HIFU transducer are focused on a specific region to induce thermal necrosis at the abnormal tissue position. With a typical electric HIFU framework, a low power waveform signal created by the commercial waveform generator is transmitted to the RF power amplifier which intensifies the waveform before applying it to the HIFU transducer through an impedance matching network [7,8,9,10]. The operation frequency of the system is modified from 1 to 5 MHz, and it is able to deliver power up to hundreds of watts. This kind of arrangement is beyond several laboratories’ budgets [11]
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