Abstract
In this study we evaluated the frequency of fusion between TMPRSS2 and ETS family members (ERG, ETV1, ETV4) in prostate cancers in patients from northern China in order to explore differences in fusion rates among regions in northern and southern China, other parts of Asia, Europe, and North America. We examined 100 prostate cancer patients, diagnosed by means of prostate biopsy; fluorescence in situ hybridization (FISH) was used to detect the expression of TMPRSS2, ERG, ETV1 and ETV4 in cancer tissue. Differences in gene fusion rates among different ethnics groups were also analyzed. Of the 100 prostate cancer patients, 55 (55%) had the fusion gene. Among the patients with the fusion gene, 46 (83.6%) patients had the TMPRSS2:ERG fusion product, 8 (14.8%) patients had TMPRSS2:ETV1 fusion, 1 (1.6%) patient had TMPRSS2:ETV4.
Highlights
Prostate cancer is a malignant tumor of the urinary system, commonly occurring in elderly men and its incidence is increasing (Weir et al, 2003)
In this study we evaluated the frequency of fusion between TMPRSS2 and ETS family members (ERG, ETV1, ETV4) in prostate cancers in patients from northern China in order to explore differences in fusion rates among regions in northern and southern China, other parts of Asia, Europe, and North America
We examined 100 prostate cancer patients, diagnosed by means of prostate biopsy; fluorescence in situ hybridization (FISH) was used to detect the expression of TMPRSS2, ERG, ETV1 and ETV4 in cancer tissue
Summary
Prostate cancer is a malignant tumor of the urinary system, commonly occurring in elderly men and its incidence is increasing (Weir et al, 2003). Different incidences of gene fusion have been reported in different regions of the world (Darnel et al, 2009; Lee et al, 2010; Mao et al, 2010; Rubio-Briones et al, 2010; Sun et al, 2010). Chinese, Korean, and Japanese studies reported different incident rates of gene fusion in prostrate cancer patients, even within Asia (Lee et al, 2010c; Mao et al, 2010b; Sun et al, 2010c). The relationship between the presence of the fusion product and PSA levels or cell classification is not well defined (Tomlins et al, 2005; Tomlins et al, 2006; Darnel et al, 2009b; Lee et al, 2010b; Sun et al, 2010b). Prostate cancer detection kits containing TMPRSS2, ERG, ETV1, and ETV4 DNA-specific probes were used for the detection of TMPRSS2:ETS fusion products in prostate biopsy specimens from northern Chinese cancer patients
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