Abstract

In the present study we have shown that the rat adrenal can respond in vitro to small increases in potassium concentration which are similar to the increases in plasma potassium concentration that have been previously shown to occur during sodium depletion. Although the chronically K-loaded rat has normal plasma [K] levels in the morning, we have shown that plasma potassium concentration is increased if measured at night, this providing a way by which the adrenal can detect increases in K balance. These observations are discussed in relation to the role of potassium in the regulation of aldosterone secretion. (Endocrinology 90: 299, 1972)

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