Abstract
SUMMARY Specimens from 466 patients with acute respiratory-tract illnesses that failed to yield a causative agent by the standard methods of virus isolation were examined in organ cultures. Seventy-three viruses (15.7 per cent) were isolated. Most of them were rhinoviruses (81.0 per cent.) but seven coronaviruses, four of which were 229E-like, were also isolated. The majority of the rhinoviruses were detected in the initial organ-culture fluids, but several blind passages were needed for the organ-culture strains of coronaviruses. Although laborious, organ culture must remain an integral part of any detailed study of acute infections of the respiratory tract.
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