Abstract
1. 1. Various s-triazine derivatives completely inhibit the turkey liver xanthine dehydrogenase catalysed oxidation of xanthine. K i values show that the relative effectiveness of these compounds is as follows: ammeline > ammelide > allantoxaidin > cyanuric acid > melamine. Oxonate, a related triazine derivative, is without effect on this enzyme. 2. 2. The differential effects of ammelide on the NADH diaphorase activities of the turkey enzyme indicate that the oxidizing substrates dichlorophenol indophenol and trinitrobenzene sulphonate inter- act with the molybdenum prosthetic groups. 3. 3. Attempts at purifying urate oxidase by affinity chromatography using oxonate (a potent inhibitor of this enzyme) coupled to aminopropanyl-Sepharose were unsuccessful.
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