Abstract
Fungicide candidate 7B3, featuring a structure of macrolactam with an oxime side chain, was evaluated through pot culture test and field efficacy trials. The results showed that 7B3 has excellent fungicidal activity against Rhizoctonia solani and Botrytis cinerea. In the pot culture test 7B3 showed good control against R. solani on cucumber and B. cinerea on tomato. In two-year four-place field efficacy trials the control of R. solani on cotton by 7B3 reached 64–92% at a rate of 140 g ai ha −1 and was better than or comparable to the commercial fungicide, carbendazin at the same dose. In a one-year one-place field efficacy trial the control effect of 7B3 against B. cinerea on cucumber reached 95% at a rate of 450 g ai ha −1 and was comparable to the commercial fungicide, huimeike at a rate of 504 g ai ha −1. Study on the dynamic distribution in cotton plants showed that 7B3 has almost no acropetal translocation or systemic activity in cotton plants. The toxicological profile of 7B3 indicated that it is a low toxicological compound and safe to humans, i.e. teratogenesis, mutagenesis and carcinogenesis tests were negative. All of the results suggested that 7B3 may be expected to be further developed as a practical fungicide.
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