Abstract
ABSTRACT This study aimed to enhance the stability and compatibility of swertiamarin by loading it on amino-functionalised graphene oxide (GO) by ultrasonication. The nanoformulation showed a new peak in the FTIR spectrum (1658 cm−1) and a coupled peak in the UV-Vis spectrum implying CO-NH2 interaction between swertiamarin and functionalised GO. The SEM image revealed a sheet-like appearance with an average particle size of 252.38 ± 86.09 nm. The nanoformulation was non-haemolytic at 200 μg/mL (<5%) whereas swertiamarin was haemolytic at 50 μg/mL concentration. The freeze-dried samples exhibited good stability at normal storage condition. The formulation and the swertiamarin displayed similar anticancer activity against HepG2 cell lines with an average IC50 value of 110 ± 0.75 μg/mL, respectively. Hence, the functionalised GO can be considered as a compatible carrier for bioactive compounds which provides better hemocompatibility and stability.
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