Abstract
A novel concept of functional state in combination of local modeling is presented as an aid in monitoring and control of complex bioprocesses. On the basis of this approach a fuzzy substrate feed rate control scheme for fed batch aerobic baker's yeast process is proposed. The control algorithm was modified to advantage by including a fuzzy term. The controlled variables were either respiratory quotient or specific growth rate estimated on-line. Effective and precise operation of the system was demonstrated by computer simulation.
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