Functional abnormalities of striatum are related to the season-specific effect on schizophrenia.

Abstract

Schizophrenia is a syndrome that is typically accompanied by delusions, hallucinations and cognitive impairments. Specifically, abundant evidences support the notion that more people diagnosed with schizophrenia are born during fall-winter than spring-summer. Although pathophysiological of schizophrenia might be associated with abnormal brain functional network, little is currently known the relationship between season and deficient brain functional network of schizophrenia. To investigate this issue, in this study 51 schizophrenic subjects and 72 healthy controls underwent MRI scanning to detect the brain functional mapping, each at spring-summer and fall-winter season throughout the year. The data-driven method was used to measure the blood oxygen metabolism variability (BOMV). Decreased BOMV in spring-summer while increased in fall-winter were observed within dopaminergic network of schizophrenic subjects, including striatum, thalamus, and hippocampus. The post hoc analysis exploring the coupling among changed BOMV regions, confirmed that a positive relationship, between pallidum and hippocampus existed in fall-winter healthy controls, but not in fall-winter schizophrenic subjects. These findings identified that seasonal effect on striatum might be associated with modulation of striatum-hippocampus. Our results provide a new insight into the role of season in understanding the pathophysiological of schizophrenia.