Abstract
In symptoms that often prove so refractory to treatment and are so vexing for patients, for which no gold standard treatment exists (1), we would like to additionally mention the use of fumaric acid esters. Before 2005, a small working group around Professor Hagedorn conducted an uncontrolled open-label study with fumaric acid esters in 12 patients with recurrent benign aphthous ulcers (2). Only in one case did the treatment have to be stopped because of adverse effects; three patients experienced complete remission and eight an improvement of their symptoms owing to longer recurrence-free intervals, more rapid healing, or a reduction in the number of aphthous ulcers. Furthermore, several hypotheses were introduced regarding the mechanism of action of fumaric acid esters in recurrent benign aphthous ulcers.
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