Abstract
Fucoidan is a sulfated polysaccharide which can be found among a number of macroalgea species. It has a broad spectrum of biological activities including anti-oxidant, anti-tumor, immunoregulation, anti-viral and anti-coagulant. The current study was performed to investigate possible protective effects of fucoidan for sulfoxaflor-induced hematological/biochemical alterations and oxidative stress in the blood of male Swiss albino mice. For this purpose, sulfoxaflor was administered at a dose of 15 mg/kg/day (1/50 oral LD50), and fucoidan was administered at a dose of 50 mg/kg/day by oral gavage alone and combined for 24 h and 7 days. Hematological parameters (RBC, HGB, HCT, MCV, MCH, MCHC, Plt, WBC, Neu, Lym and Mon), serum biochemical parameters (AST, ALT, GGT, LDH, BUN, Cre and TBil), and serum oxidative stress/antioxidant markers (8-OHdG, MDA, POC and GSH) were analyzed. The results indicated that sulfoxaflor altered hematological and biochemical parameters and caused oxidative stress in mice; fucoidan ameliorated some hematological and biochemical parameters and exhibited a protective role as an antioxidant against sulfoxaflor-induced oxidative stress.
Highlights
Received: 3 December 2021In recent years, attention has been focused on whether naturally occurring compounds can modulate the effects of various toxic xenobiotics
The parameters were analyzed for determination of the effects of sulfoxaflor and fucoidan on hematological parameters in male mice including red blood cell (RBC) count, hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelets (Plt), white blood cell count (WBC), neutrophil (Neu %), lymphocyte (Lym %), monocyte (Mon %), eosinophil (Eos %)
Sulfoxaflor and fucoidan showed no significant effect on RBC count, HGB level, HCT, MCV, MCH, Neu count, Lym count, Mon count and Plt count after 24-h treatment, and on RBC, MCV, MCH, Neu, Lym, and Plt after 7-d treatment when compared with the control
Summary
Attention has been focused on whether naturally occurring compounds can modulate the effects of various toxic xenobiotics. These studies reported that antioxidant compounds obtained from natural sources prevented various tissues from toxic effects of xenobiotics [1]. One of these natural compounds is sulfated polysaccharide fucoidan isolated from brown macroalgae species such as Macrocystis pyrifera, Fucus vesiculosus, Laminaria japonica. Several studies have reported that fucoidan has a protective role against the toxicity of numerous xenobiotics including alcohol [10], acetaminophen [11], carbon tetrachloride [12], insecticide diazinon [13], fungicide cholorothalonil [14] due to its antioxidant, anti-inflammatory and anti-apoptotic properties
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
