Abstract
The front cover picture was designed by Emina Mehić and Lucija Hok, and illustrated by Josipa Zeba. (© Josipa Zeba. Reproduced with permission.) It depicts the halohydrin dehalogenase-catalysed conversion of epoxides. Extensive screening of enzymes from group B revealed several highly enantioselective transformations, with HheB showing higher enantioselectivity and activity toward a larger panel of substrates compared to HheB2. By using site-directed mutagenesis, residues 120 and 125 were found to be responsible for higher enantioselectivity of HheB compared to HheB2. Due to remarkable activity and enantioselectivity, B-group HHDHs emerged as a catalyst of choice for the synthesis of bulky tertiary alcohols. Details can be found in the Research Article by Majerić Elenkov, Vianello and co-workers (E. Mehić, L. Hok, Q. Wang, I. Dokli, M. Svetec Miklenić, Z. Findrik Blažević, L. Tang, R. Vianello, M. Majerić Elenkov, Adv. Synth. Catal. 2022, 364, XXXX–XXXX; DOI: 10.1002/adsc.202200342)
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