From agricultural chemistry to toxicology: the AOAC and the politics of validation

EFSA Supporting PublicationsVolume 15, Issue 1 1366E Technical reportOpen Access Explanatory note on the selection of forage material suitable for the risk assessment of GM feed of plant origin European Food Safety Authority (EFSA), European Food Safety Authority (EFSA)Search for more papers by this authorMichele Ardizzone, Michele ArdizzoneSearch for more papers by this authorClaudia Paoletti, Claudia PaolettiSearch for more papers by this authorElisabeth Waigmann, Elisabeth WaigmannSearch for more papers by this author European Food Safety Authority (EFSA), European Food Safety Authority (EFSA)Search for more papers by this authorMichele Ardizzone, Michele ArdizzoneSearch for more papers by this authorClaudia Paoletti, Claudia PaolettiSearch for more papers by this authorElisabeth Waigmann, Elisabeth WaigmannSearch for more papers by this author First published: 29 January 2018 https://doi.org/10.2903/sp.efsa.2018.EN-1366Citations: 6 Requestor: EFSA Question number: EFSA-Q-2017-00614 AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References Allen VG, Batello C, Berretta EJ, Hodgson J, Kothmann M, Li X, McIvor J, Milne J,. Morris C,. Peeters A and Sanderson M, 2011. An international terminology for grazing lands and grazing animals. Grass and Forage Science, 66, 2– 28. EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms), 2011. EFSA Panel on Genetically Modified Organisms (GMO); Scientific Opinion on Guidance for risk assessment of food and feed from genetically modified plants. EFSA Journal 2011; 9(5):2150, 37 pp. https://doi.org/10.2903/j.efsa.2011.2150 U Meier (ed.), 2001. Growth stages of mono-and dicotyledonous plants, 2nd edition. BBCH Monograph. Federal Biological Research Centre for Agriculture and Forestry, Bonn, Germany. McDonald P, Edwards RA, Greenhalgh JFD, Morgan CA, Sinclair LA, Wilkinson RG, 7th ed., 2011. Animal Nutrition,. Pearson education limited. OECD (Organisation for Economic Co-operation and Development), 2002a. Consensus document on compositional considerations for new varieties of sugar beet: key food and feed nutrients and anti-nutrients. Series on the Safety of Novel Foods and Feeds, No. 3. ENV/JM/MONO(2002)4 OECD (Organisation for Economic Co-operation and Development), 2002b. Consensus document on compositional considerations for new varieties of maize (Zea maize): key food and feed nutrients, anti-nutrients and secondary plant metabolites. Series on the Safety of Novel Foods and Feeds, No 11. ENV/JM/MONO(2004)16. OECD (Organisation for Economic Co-operation and Development), 2009. Consensus document on compositional considerations for new varieties of cotton (Gossypium hirsutum and Gossypium barbadense): key food and feed nutrients and anti-nutrients. Series on the Safety of Novel Foods and Feeds, No 11. ENV/JM/MONO(2004)16. OECD (Organisation for Economic Co-operation and Development), 2011. Revised consensus document on compositional considerations for new varieties of low erucic acid rapeseed (Canola): key food and feed nutrients, anti-nutrients and toxicants. Series on the Safety of Novel Foods and Feeds, No. 24. ENV/JM/MONO (2011)55. OECD (Organisation for Economic Co-operation and Development), 2012. Revised consensus document on compositional considerations for new varieties of soybean [Glycine max (L.) merr.]: Key food and feed nutrients, anti-nutrients, toxicants and allergens. Series on the Safety of Novel Foods and Feeds, No. 25. ENV/JM/MONO(2012)24 OECD (Organisation for Economic Co-operation and Development), 2015. Safety assessment of foods and feeds derived from transgenic crops, Volume 1, novel food and feed safety, OECD publishing, Paris. Citing Literature Volume15, Issue1January 20181366E ReferencesRelatedInformation

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Modification of the current MRLs for acetamiprid in flowering brassica and figs.

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The Organization for Economic Cooperation and Development (OECD) is the least written about and least well understood of the global multilateral economic institutions. Paradoxically, leading commentators ceaselessly refer to the centrality of the OECD to contemporary global governance, yet rarely has the organization been the subject of sustained academic scrutiny. For instance, Joseph Nye (2002: 144) argued that the OECD, in collaboration with the International Monetary Fund (IMF) and the World Trade Organization (WTO), provides ‘a framework of rules for the global economy’. Similarly, Held et al. (1999: 84) cite the OECD among the ‘key multilateral economic fora’ common to all ‘states in advanced capitalist societies’. Nevertheless, having identified the importance of the OECD, these and many other observers proceed to marginalize the role of the organization preferring instead to focus on the IMF, the World Bank and the WTO. Equally, as the other contributions to this volume testify, book-length accounts of the activities of the WTO, the IMF, the World Bank and other leading institutions such as the Group of 7/8 (G7/8), which now has an entire book series devoted to it, are commonplace. In contrast, apart from a smattering of texts authored by the OECD’s own staff (OECD 1971; Sullivan 1997) and a small literature examining the organization’s role in the global trading system (Blair 1993; Cohn 2002), the last single-authored book written in English by an outsider and focussing exclusively on the OECD’s role in global affairs was published nearly forty years ago (Aubrey 1967; Woodward 2007a). More specialized work detailing the history and evolution of transatlantic governance is largely devoid of references to the OECD. One contributor to Gardner and Stefanova’s collection The New Transatlantic Agenda (2001) asserts that ‘the “OECD world” is, first of all, a transatlantic world’ (May 2001: 185) but there is only one further reference to the organization in the volume. Pollack and Shaffer’s (2001) Transatlantic Governance in the Global Economy and Richard Cooper’s (1968) classic study of economic management among the Atlantic community, The Economics of Interdependence, provide greater coverage of the OECD and its predecessor the Organization for European Economic Cooperation (OEEC) but again these references are sporadic and fragmented. A cursory survey of articles published in the last decade by what, according to the ISI Social Sciences Citation Index, are thetwenty highest impact international relations journals reveals a comparable pattern (see Table 3.1). In purely quantitative terms the OECD does not fair too badly. The WTO is clearly the frontrunner, being the subject of 211 articles during the period, but the OECD with thirty-four articles is only slightly behind the IMF (48) and is ahead of the World Bank (26) and the G7/8 (5). However, only 15 of these 34 articles contain substantive material about the organization, its work or its broader contribution to global governance. The remaining articles were using OECD countries as a basis for comparison. Finally, the OECD lacks the public profile associated with other international organizations. Anti-globalization protests have marred OECD gatherings in Paris (February 1998), Bologna (June 2000) and Naples (March 2001) but typically OECD meetings are low-key affairs passing off without the media comment, sabre rattling and general razzmatazz that accompany the IMF, WTO and the G8.

To become a member of the Organisation for Economic Co-operation and Development (OECD), Indonesia needs to adjust tax regulations and laws in accordance with the standards or guidelines set by the Organisation for Economic Co-operation and Development (OECD). There are many aspect that included if Indonesia want to become a member of the Organisation for Economic Co-operation and Development (OECD). One aspect of taxation that Indonesia needs to adjust is the Inclusive Framework on Base Erosion and Profit Sharing (BEPS). Indonesia already show their commitment to Inclusive Framework on Base Erosion and Profit Sharing (BEPS). However, in implementation, Indonesia has not yet applied the principle of Inclusive Framework on Base Erosion and Profit Sharing (BEPS). Therefore, this article aims to analyse what domestic tax regulations or laws need to be adjusted by the Indonesian Government to comply with this Inclusive Framework. This research is qualitative research with a normative juridical approach that relies on literature study as a data collection technique. The results of this research show that the Indonesian Government needs to make adjustments to tax regulations in each of the 15 action plans of the Inclusive Framework on Base Erosion and Profit Sharing (BEPS) and Indonesia needs to do effectively if Indonesia want to become a member of the Organisation for Economic Co-operation and Development (OECD)

The Organisation for Economic Co-operation and Development (OECD) was established in 1960, succeeding the Organisation for European Economic Co-operation (OEEC). Its mission is to promote sustainable economic growth, employment, and financial stability through cooperation and transparency among member countries. The OECD operates under a soft-law framework, utilizing non-binding instruments such as guidelines and peer reviews to influence policy and promote best practices. It consists of the Council, committees, and the Secretariat, which work iteratively to develop and implement policies. The OECD’s work spans diverse areas including taxation, trade, education, and environmental policies, contributing significantly to global economic integration. Its influence extends beyond its thirty-eight member countries through partnerships, global forums, and the inclusion of non-member countries in its activities. Despite challenges in maintaining relevance, the OECD continues to adapt to emerging global issues, emphasizing consensus-building and evidence-based policy recommendations.

Decentralized Administrative Law in the Organization for Economic Cooperation and Development

How affordable is health care in the United States and other countries?

Alþjóðastofnanir á borð við Efnahags- og framfarastofnunina (OECD), Sameinuðu þjóðirnar (SÞ), Alþjóðagjaldeyrissjóðinn (AGS) og Alþjóðabankann eru þekktar fyrir að standa að baki útbreiðslu hugmynda, gilda og stefnumála um heim allan. Á 10. áratugnum jókst áhugi fræðimanna á viðfangsefni sem kallað er hér stefnuyfirfærsla (e. policy transfer). Tilraunir fræðimanna fólust m.a. í því að setja ramma utan um nálgunina og skýra af hverju yfirfærsla á sér stað, við hvaða aðstæður, á hvaða stigi o.s.frv. Fátt hefur verið meira rannsakað innan stjórnsýslufræðanna undanfarna áratugi erlendis en viðfangsefnið hefur lítið borið á góma hér á landi. Þrátt fyrir mikinn áhuga á viðfangsefninu alþjóðlega hefur nálgunin verið gagnrýnd þar sem hún er m.a. talin vera of lýsandi og kenningarlega veik. Hafa ekki embættismenn og stjórnmálamenn stolið hugmyndum frá hvor öðrum í aldir? Í ár verður Efnahags- og framfarastofnunin (OECD) 60 ára. Ísland er eitt af stofnaðildarríkjunum og því kominn tími til að rýna þetta langa samstarf sem íslensk stjórnsýsla hefur átt við OECD. Tilgangur þessarar greinar er að fjalla um starfsemi OECD og meta áhrif hennar á íslenska stefnumótun. Í fyrsta hluta greinarinnar er annars vegar fjallað um forvera OECD sem var Efnahagssamvinnustofnun Evrópu (OEEC) og hvernig hún lagði grunninn að því hvernig OECD starfar í dag. Hins vegar er farið ítarlega yfir hlutverk og skipulag OECD og þær áskoranir sem stofnunin hefur staðið frammi fyrir á undanförnum áratugum. Í öðrum hluta er aðferðin stefnuyfirfærsla skoðuð nánar. Aðferðin er skilgreind auk þess sem fjallað er um helstu leikendur. Tilraun er gerð til að ramma inn helstu afbrigði stefnuyfirfærslna og rætt er um sjálfviljuga og þvingaða yfirfærslu. Að lokum er fjallað um þátttöku Íslands á vettvangi OECD. Til að meta að hvaða leyti íslensk stjórnvöld nýta sér afurðir OECD við stefnumótun hér á landi er stuðst við gögn úr árangurskönnunum stofnunarinnar.

This scientific article is devoted to the analysis of challenges, trends, and opportunities for rural development of the OECD (Organization for Economic Cooperation and Development) member countries. Agriculture plays a crucial role in global food security but faces significant challenges such as climate change, demographic change, and economic hardship. The importance of the member countries of the Organization for Economic Cooperation and Development (OECD) in the global development of the agro-industrial complex cannot be underestimated. OECD countries occupy an important place in the world production and export of agricultural products, which is pivotal in ensuring global food supply. They attract significant investments in the agro-industrial sector, contributing to the modernization of production technologies, the introduction of innovations, and increased productivity. OECD countries have a developed scientific base that helps improve agricultural practices, implement environmentally friendly production methods, and create sustainable rural development. In addition, OECD countries influence the formation of international standards and policies related to the agro-industrial complex. They cooperate in trade in agricultural products, develop strategies to ensure food security, and support the development of rural communities. Thus, the OECD countries play an essential role in the global expansion of the agro-industrial complex, attracting investments, introducing the latest technologies, defining standards, and cooperating with other countries. Their efforts aim to achieve sustainable, innovative, and socially responsible development of the agro-industrial sector, which is essential for ensuring food security and improving the population's quality of life. The article analyzes the current state of production and consumption of critical products of the OECD agro-industrial complex. It considers opportunities for the development of agriculture, particularly in the context of sustainable development, technological progress, and innovative approaches. Within the framework of this article, both opportunities and challenges and trends of systemic development of agriculture in OECD countries are analyzed in the medium term. Conclusions on the research topic are formed. Keywords: agriculture, OECD, agro-industrial complex, agro-industrial complex, development of agriculture.

The article examines the implementation of the Organization for Economic Cooperation and Development (OECD) Recommendation on Effective Public Investment Across Levels of Government in Ukraine. The article covers the nature and peculiarities of the OECD Recommendation and analyzes the process of its implementation by Ukraine. The purpose of the Recommendation on Effective Public Investment Across Levels of Government is to help governments at all levels assess the strengths and weaknesses of their public investment capacity using a country-wide approach and identify priorities for improvement. Given the downward trend in public investment, especially in times of crisis, it is very important for governments at all levels to be efficient, i.e., to be able to deliver better results with less costs and to spend more wisely. The problem is much broader than just funding investment, as it concerns the most efficient use of investment funds, for which different levels of government may lack appropriate management tools even if investment funding is available. The scope of the Organization for Economic Cooperation and Development and the list of legal instruments it is developing are described. The article outlines three systematic challenges to multi-level public investment management that impede the achievement of the best outcomes: coordination challenges, capacity challenges, and framework challenges. It notes that to address these issues, the OECD has developed a Recommendation on Effective Public Investment Across Levels of Government, which takes into account the above challenges and is built on three key pillars: coordination of public investment at different levels of government and policy; strengthening public investment capacity and promoting policy learning at all levels of government; and ensuring an appropriate framework for public investment at all levels of government. The framework covers twelve principles, which in turn include specific steps for implementing the OECD Recommendation in practice. The principles set out in the Recommendation are applicable to national, regional, and local governments and address aspects that are relevant to other stakeholders in public investment. The implementation of the OECD Recommendation on Effective Public Investment Across Levels of Government will allow Ukraine to benefit from the experience of successful OECD countries in this area, and the increase in the efficiency of public investment will signal to foreign investors that investing in Ukraine is a viable option. The article also examines the steps taken by Ukraine on the way to establishing and strengthening cooperation with the Organization for Economic Cooperation and Development, in particular in terms of implementing the Recommendation, and outlines the main problematic issues on this path. Ukraine’s cooperation with the Organization for Economic Cooperation and Development is extremely important for ensuring its economic well-being, both at the national, regional, and local levels.

The description of quantitative structure-activity relationship (QSAR) models has been a topic for scientific research for more than 40 years and a topic within the regulatory framework for more than 20 years. At present, efforts on QSAR development are increasing because of their promise for supporting reduction, refinement, and/or replacement of animal toxicity experiments. However, their acceptance in risk assessment seems to require a more standardized and scientific underpinning of QSAR technology to avoid possible pitfalls. For this reason, guidelines for QSAR model development recently proposed by the Organization for Economic Cooperation and Development (OECD) [Organization for Economic Cooperation and Development (OECD) (2007) Guidance document on the validation of (quantitative) structure-activity relationships [(Q)SAR] models. OECD Environment Health and Safety Publications: Series on Testing and Assessment No. 69, Paris] are expected to help increase the acceptability of QSAR models for regulatory purposes. The guidelines recommend that QSAR models should be associated with (i) a defined end point, (ii) an unambiguous algorithm, (iii) a defined domain of applicability, (iv) appropriate measures of goodness-of-fit, robustness, and predictivity, and (v) a mechanistic interpretation, if possible [Organization for Economic Cooperation and Development (OECD) (2007) Guidance document on the validation of (quantitative) structure-activity relationships [(Q)SAR] models. The present perspective provides an overview of these guidelines for QSAR model development and their rationale, as well as the promises and pitfalls of using QSAR approaches and these guidelines for predicting metabolism and toxicity of new and existing chemicals.

Rent-seeking is a non-productive activity and is formed mostly following government intervention in the economy. In rent-seeking activities, resources and efforts are spent on achieving a monopoly position, and instead of being provided with productive activities, it is spent on distributive struggles that in the long run change the structure of economic and social incentives and lead to heavy welfare losses and heavy social costs. Therefore, identifying the factors affecting Rent-seeking helps us to reduce it and achieve economic growth. Property rights is one of the influential institutional variable that effect on rent-seeking. Property rights affect the motivation of individuals and the use of resources and can encourage productive activities such as the accumulation of skills, the development of new products and the creation of production technology, or can lead people to addictive, corrupt and crime behaviors. In countries where private property rights are well defined and enforced, the legal rights of investors are protected and investors are more willing to invest in financial institutions and the financial market flourishes. But if property rights are not well defined and enforced, people's motivation is distorted, people turn to rent-seeking, and their motivation to participate in productive work is greatly reduced.Due to the importance of property rights in the formation of rent-seeking, in this study, this issue is examined in addition to the impact of other variables such as education , democracy, economic growth, militarization, inflation and oil rent on rent-seeking. For this purpose, two groups selected member countries of the Organization of the Petroleum Exporting Countries (OPEC) and the Organization for Economic Cooperation and Development (OECD) have been studied from 1996 to 2017. To achieve this goal, a panel data model has been used. First, with the Hadri-Rao test, which considers structural breaks, the stationarity of the data was investigated, pre-estimation tests were performed, and then due to cross-sectional dependency, variance heterogeneity and autocorrelation between the residual errors in each selected Organization of the Petroleum Exporting Countries (OPEC) countries and selected member countries of the Organization for Economic Co-operation and Development (OECD) are estimated by the Driscoll-Cray method. The results show that in both groups, democracy and property rights and economic growth have a significant negative impact, both inflation and militarization has a positive and significant effect on rent-seeking. Also in the selected member countries of the Organization for Economic Co-operation and Development, the rent-seeking decreases as the state of education improves. However, this variable has a significant and positive effect on the rent-seeking in oil-exporting countries. On the other hand, in oil-exporting countries, oil rent have a positive and significant effect on rent-seeking, when oil rent increase, people have less motivation to do productive work and they do more distributive activities.

During the last two decades the micronucleus (MN) test has been extensively used as a genotoxicity screening tool of chemicals and in a variety of exploratory and mechanistic investigations. The MN is a biomarker for chromosomal damage or mitotic abnormalities since it can originate from chromosome fragments or whole chromosomes that fail to be incorporated into daughter nuclei during mitosis (Fenech et al., Mutagenesis 26: 125-132, 2011; Kirsch-Volders et al., Arch Toxicol 85: 873-899, 2011). The simplicity of scoring, accuracy, amenability to automation by image analysis or flow cytometry and the readiness to be applied to a variety of cell types either in vitro or in vivo made it a versatile tool that contributed to a large extent in our understanding of key toxicological issues related to genotoxins and their effects at the cellular and organism levels. Recently, the final acceptance of the in vitro MN test Organization for Economic Cooperation and Development (OECD) guideline 487 (OECD, Guideline for testing of chemicals: in vitro mammalian cell micronucleus test 487: in vitro mammalian cell micronucleus test (MNVIT). Organization for Economic Cooperation and Development, Paris, 2010) together with the standard in vivo MN test OECD guideline 474 (OECD, Guideline for the testing of chemicals no. 474 mammalian erythrocyte micronucleus test. Organization for Economic Cooperation and Development, Paris, 1997) further positioned the assay as a key driver in the determination of the genotoxicity potential in exploratory research as well as in the regulatory environment. This book chapter covers to some extent the protocol designs and experimental steps necessary for a successful performance of the MN test and an accurate analysis of the MN by the flow cytometry technique.