Abstract
Many schemes have been proposed to measure physiological pH by conjugating pH-sensitive dyes with Upconverting Nanoparticles (UCNPs). However, the signal transduction is typically achieved by a combination of photon reabsorption and Förster resonant energy transfer (FRET) between UCNPs and dyes. While FRET senses the pH in the immediate vicinity of the sensor, photon reabsorption is strongly affected by the global environment, potentially obscuring the local pH values. In this presentation, we report a new sensing scheme that detects only the contributions by FRET and is insensitive to photon reabsorption, making it the first demonstration of truly local pH measurements.
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