Abstract
Objectives:To determine the frequency of impaired fasting glucose in first degree relatives of people with Type-II diabetes and its association with BMI.Methods:This cross-sectional study was conducted in Diabetic clinic of Shaikh Zayed Hospital, Lahore from July to December 2017. Individuals aged ≥35 years, first degree relatives of people with Type-II diabetes, were selected and their fasting blood glucose levels were checked twice a week apart. Study participants were divided into 3 groups. Group-I were those with normal fasting blood glucose (FBS: <100mg/dl), Group-II were those with impaired fasting glucose (100-125mg/dl), considered as high risk and Group-III included those who turned out to be having frank diabetes (FBS: ≥126mg/dl). Exclusion criteria were known diabetes and pregnancy. Proportions of impaired fasting glucose levels versus BMI were compared using Chi-square test. Significance was considered at P <0.001.Results:A total of hundred subjects were included in the study with the mean age of 44.27 years. Sixty percent participants had normal FBS, 31% showed impaired FBS and 09% had frank diabetes (P <0.001). Significant association was found between impaired fasting glucose and BMI, as with increasing BMI the frequency of impaired fasting glucose increases.Conclusion:First-degree relatives of people with Type-II diabetes showed higher frequency of impaired fasting glucose and obesity was an important risk factor.
Highlights
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both.[1]
We have divided the subjects into three groups on the basis of fasting blood glucose levels
Rodríguez-Moran M et al, showed the presence of family history of diabetes in first degree relatives is associated with impaired fasting glucose, even in the absence of obesity.[14]
Summary
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both.[1] Type-2 diabetes mellitus is an important public health problem worldwide, and its prevalence is increasing in both developed and developing nations.[2] Pakistan is in the top 10 countries for absolute increase in diabetes prevalence. Prevalence of diabetes in Pakistan is high, overall prevalence is 26.3%, of which 19.2% have known diabetes and 7.1% are newly diagnosed diabetics. Prevalence of impaired fasting glucose is 14.4%.3. In 2019, over 19 million adults in Pakistan are Prevalence of impaired fasting glucose is 14.4%.3 In 2019, over 19 million adults in Pakistan are
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