Frequency of histopathological changes in gall bladder mucosa associated with gallstones

Abstract

IntroductionAim and objective is to study the histopathological changes in gall bladder mucosa associated with gallstones and find out the important facts associated with carcinoma of gallbladder. Compare and correlate the study findings with similar studies done in the past in different part of India. Material and methodIt is a cross-sectional hospital based study done in Santosh Medical College and Hospital Ghaziabad. The duration of this study is 2 years extending from January 2014 to January 2016. Study performed in total 131 open cholesistectomy specimens with complete gallstones. We included male and female patients of all the age group. Patient of gallstones diagnosed by radiology & recommended for cholecystectomy formed the study population. Autolysed cholecystectomy specimen & cholecystectomy specimen without gallstone were excluded from this study. It is the part of PhD thesis work done under the guidance of professor Dr. Vishram Singh. ResultOn the basis of microscopic finding maximum number of specimens had chronic cholecystitis 97.7%, followed by rokitansky ascoff sinuses 22.9%, muscular hyperplasia 15.3%, epithelial hyperplasia 8.4%, fibrosis & ulceration 3.8%, carcinoma 3.1%, antral metaplasia 2.3%, xanthogranulomatous cholecystitis 2.3%, eosinophilic cholecystitis and intestinal metaplasia each present with 0.8%. In this study carcinoma is usually present with pigment type gallstone. DiscusionMost of the gall stones having rough surfaces which causing continuous irritation in the mucosa of gall bladder. Continuous presence for the long time period of gall stones ultimately causes the series of histopathological changes in gall bladder.