Frequency of Gastrointestinal Problems in Neurofibromatosis Type 1: The Johns Hopkins Experience (P07.105)

Abstract

Objective: This study proposes to estimate the frequency of gastrointestinal (GI) complications in the neurofibromatosis type 1 population known to the Comprehensive Neurofibromatosis Center at Johns Hopkins Hospital. Background Although the neurological complications associated with neurofibromatosis type 1 (NF1) are widely known, GI complications have been largely undocumented though they can greatly affect morbidity in this population. Plexiform neurofibromas can lead to intestinal obstruction. Central or peripheral neurofibromas may lead to autonomic instability compromising gut function. While patients with NF1 often report GI complications to their providers, the comprehensive study of these complications has not been undertaken. Design/Methods: Chart review on all patients with NF1 at Johns Hopkins Hospital. Subjects were separated by age (>18 years or Results: 309 subjects >18 years and 196 subjects Conclusions: GI complications are common in adults and children with NF1. None of the complications noted were due to a GI stromal tumor. Screening of GI complications should be included in adults and children with NF1. Disclosure: Dr. Wolf has nothing to disclose. Dr. Bergner has nothing to disclose. Dr. Obeng has nothing to disclose. Dr. Blakeley has nothing to disclose.