FREQUENCY OF CYTOMEGALO VIRUS IGM AND IGG IN PRE RENAL TRANSPLANT DONORS AND RECIPIENTS

Abstract

Abstract One of the most opportunistic infection in kidney transplant recipients is Cytomegalovirus. This study was conducted to find the frequency of cytomegalo-virus IgM and IgG in kidney transplant donors and recipients. Methods: We carried out retrospective analysis of Ashraf H.S. 1 Professor and Head of Department Kidney Transplant Unit Sheikh Zayed Hospital, Lahore Saeed M. 2 PGR, Nephrology Department Sheikh Zayed Hospital, Lahore Hussain S.W. 3 Assistant Professor Department Of Urology Sheikh Zayed Hospital, Lahore Mateen F.E. 4 PGR, Nephrology Department Sheikh Zayed Hospital, Lahore Hussain N. 5 Assistant Professor Kidney Transplant Unit Sheikh Zayed Hospital, Lahore Ibrahim M.N. 6 Senior Registrar Kidney Transplant Unit Sheikh Zayed Hospital, Lahore laboratory values of cytomegalovirus IgG and IgM antibodies of all donors and recipients presented from 2006 to 2013 to National Institute of Kidney diseases Sheikh Zayed Hospital Lahore Pakistan. Results: Total no. of patients were 410 (205 donors and 205 recipients). Among recipients 169 (82%) were male and 36 (18%) female while among donors 125 (60%) were male and 80(40%) female. Total 05 (2.4 %) recipients were CMV IgG negative and 03 (1.4%) CMV IgM positive. Out of two hundred five recipients 200 (98%) were IgG positive and 202(99%) were IgM negative. All the donors were CMV IgM negative and CMV IgG positive. Conclusion: There is very high frequency of CMV IgM and IgG positivity in donors and recipient of renal transplant in our population so we should consider prophylactic therapy. Keywords: CMV, Renal Transplant, Prophylactic Therapy.