Abstract
Frequency domain phase-resolved optical Doppler tomography (ODT) was developed with Doppler variance imaging capability. It is shown that utilizing the frequency domain method, phase-resolved ODT can achieve much higher imaging speed and velocity dynamic range than the time domain method. Structural, Doppler and Doppler variance images of fluid flow through glass channels were quantified and blood flow through vessels were demonstrated in vivo.
Highlights
Optical Doppler tomography (ODT), named Doppler optical coherence tomography (Doppler OCT), is capable of measuring microflows using the optical Doppler effect [1,2]
ODT systems are implemented in the time domain
In the time domain ODT, mechanical devices are required for axial scanning (A-line scanning) and limit the imaging speed and velocity dynamic range
Summary
Optical Doppler tomography (ODT), named Doppler optical coherence tomography (Doppler OCT), is capable of measuring microflows using the optical Doppler effect [1,2]. To further the study of microflows, a Doppler variance algorithm has been added to the phase-resolved ODT [5]. Real-time 2D flow imaging has been achieved with the time domain ODT, 3D mapping of complex flows in microfluidic networks requires even higher speed and better sensitivity.
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