Abstract
Diet is considered to be a significant factor in cancer prevention and therapy. Many food components reveal anticancer activity. The increasing number of experiments concerning the anticancer potential of chemical compounds, including food components, is a challenge for data searching. Specialized databases provide an opportunity to overcome this problem. Data concerning the anticancer activity of chemical compounds may be found in general databases of chemical compounds and databases of drugs, including specialized resources concerning anticancer compounds, databases of food components, and databases of individual groups of compounds, such as polyphenols or peptides. This brief review summarizes the state of knowledge of chemical databases containing information concerning natural anticancer compounds (e.g., from food). Additionally, the information about text- and structure-based search options and links between particular internet resources is provided in this paper. Examples of the application of databases in food and nutrition sciences are also presented with special attention to compounds that are interesting from the point of view of dietary cancer prevention. Simple examples of potential database search possibilities are also discussed.
Highlights
An appropriate diet is considered to be an important factor in cancer therapy and prevention.Therapeutic and preventive role of dietary compounds against cancer is the object of extensive studies, continuously presented in numerous reviews [1,2,3,4]
In our previous publication [16], we presented general information concerning databases of compounds with low molecular weight, their enzymatic reactions and metabolism
The aim of this review is to provide a brief description of free accessible databases annotating compounds, e.g., food components of interest in the context of anticancer properties
Summary
An appropriate diet is considered to be an important factor in cancer therapy and prevention. Polyphenols are considered to be major anticancer and antioxidant food components [34] They interact with many proteins, including these known as drug targets according to the DrugBank database. Specialized databases of anticancer drugs, including natural products (MetaComBio category: “Pharmacologically active compounds”). The information about enzymes involved in the metabolism of drugs and other bioactive compounds, including food components, is available in the KEGG database [38]. PubChem CID (Compound ID) serves as an unambiguous identifier, recommended for use in research articles and enabling searches using special programs, such as Chemical Translation Service [52] Metabases such as Labworm or MetaComBio [49] provide access to many databases and other bioinformatic and cheminformatic tools. SciFinder, provided by American Chemical Society or OmicTools, provided by omicX company)
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