Abstract
The localization of function to different parts of the CNS has a long and fascinating history which, with modern radionucleotide techniques, is continuing to this day and which is still incomplete. For example, little is still known of the central connections of the olfactory tract. Thomas Willis (1621–75), in his Cerebri anatome published in 1664, suggested that the cerebrum controls voluntary, and the cerebellum involuntary movements, in what was probably an inspired guess. It was not until 1809 that Luigi Rolando (1773–1831) of Sardinia showed, by animal experiments in which he ablated one or other of these structures, that Willis's conjecture was correct.
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