Abstract
Objective: To determine the impact of frailty on risk of non-elective hospitalizations and length of stay (LOS) in patients with fibrotic interstitial lung disease (ILD). Methods: Frailty was measured as the proportion of deficits present on a 42-item patient-reported frailty index (FI), with frailty defined by a FI>0.21. Mixed effects poisson regression was used to estimate incidence rate ratios (IRRs) for number of non-elective hospitalizations within 6 months of frailty assessment and Cox proportional hazard ratios (HRs) to analyze time to discharge. Results: 540 patients with fibrotic ILD were recruited, including 100 with idiopathic pulmonary fibrosis (IPF). Median FI was 0.21 (IQR 0.09-0.33) with 50% of patients classified as frail. A total of 214 hospitalizations were recorded, including 131 that were respiratory-related. IRRs for all-cause and respiratory-related hospitalizations were both 1.03 (95%CI 1.02-1.04, p Conclusion: Frailty independently predicts number and length of all-cause and respiratory-related hospitalizations in patients with fibrotic ILD.
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