Frailty and health care utilisation among middle-aged and older adults in Canada: variations by sex, immigration status and race
Purpose Frailty as a predictor of health care utilisation is well-studied; however, the role of sociodemographic factors in shaping this relationship remains less understood. This study aimed to use nationally representative Canadian data to examine how the association between frailty and health care utilisation varies by sex, immigration status and race. Design/methodology/approach A total of 70,825 respondents aged ≥ 45 were included in the study from the public use microdata files of the Canadian Community Health Survey 2013–2014. The outcome measures included general practitioner (GP) visits, specialist (SP) visits and inpatient admissions. A 28-item frailty index (FI) was constructed to measure the cumulative deficit related to age. Logistic and count data regression models were used to examine the association between FI and health care utilisation, adjusting for potential covariates. Findings Average (standard deviation) number of GP visits, SP visits and inpatient admissions was 2.91 (±3.69), 1.00 (±2.07) and 0.58 (±3.13), respectively, in the past 12 months. About 57% of the respondents were in low (≤ 0.1), followed by 27.2% in medium (0.11–0.20), 9.3% in high (0.21–0.30) and 6% in very high (≥ 0.31) FI groups. FI was positively associated with health care utilisation. However, the magnitude of association across most outcomes was consistently larger among males, immigrants and visible minorities. For instance, the very high frailty (≥ 0.31) had a larger association with the number of SP visits for visible minorities compared to Whites. Originality/value The findings underscore the importance of considering sociodemographic factors in addressing health care needs among frail populations. Future research can investigate how sociodemographic factors intersect and influence the relationship between frailty and health care use.
- Research Article
4
- 10.1016/j.socscimed.2005.08.027
- Oct 20, 2005
- Social Science & Medicine
Correlations of siblings’ and mothers’ utilisation of primary and hospital health care: A record linkage study in Western Australia
- Research Article
1
- 10.1038/s41598-024-67238-9
- Jul 16, 2024
- Scientific Reports
This study aimed to assess the impact of the COVID-19 pandemic on general practitioner (GP), specialist, and dentist visits among 40 million Iranians covered by the Social Security Organization (SSO). A monthly interrupted time series analysis was conducted over a period of 72 months, including—47 months before the pandemic and 25 months after its onset. The outcomes variables were monthly number of GP, specialist, and dentist visits per 1000 SSO-insured individuals. The analysis was performed by total visits, visits to the SSO direct sector, and visits to the indirect sectors. The study found that in the first month of the pandemic, the number of visits per 1000 insured individuals significantly decreased for visits to GPs (by 51.12, 95% CI −64.42 to −37.88), visits to specialists (by 39.11, 95% CI −51.61 to −26.62), and visits to dentists (by 6.67, 95% CI −8.55 to −4.78). However, during the subsequent months of the pandemic, there was a significant increase in the number of monthly visits for all three categories, with GPs experiencing the highest increase (1.78 visits per 1000 insured), followed by specialists (1.32 visits per 1000 insured), and dentists (0.05 visits per 1000 insured). Furthermore, prior to the pandemic, the number of monthly GP visits per 1000 insured individuals was statistically significantly lower in the indirect sector compared to the direct sector (45.79, 95% CI −52.69 to −38.89). Conversely, the direct sector exhibited lower rates of specialist visits (25.84 visits per 1000 insured individuals, 95% CI 22.87 to 28.82) and dentist visits (0.75 visits per 1000 insured individuals, 95% CI 0.12 to 1.36) compared to the indirect sector. Additionally, the study found that in the first month of the pandemic, the monthly number of GP visits in the indirect sector significantly increased by 34.44 times (95% CI 24.81 to 44.08) compared to the direct sector. For specialist visits and dentist visits, the increase was 3.41 (95% CI −5.87 to 12.69) and 5.01 (95% CI 3.48 to 6.53) per 1000 insured individuals, respectively. Overall, the findings of this study demonstrate statistically significant disruptions in GP, specialist, and dentist visits during the COVID-19 pandemic, although some recovery was observed. Both the direct and indirect sectors experienced decreased visits.
- Research Article
18
- 10.1016/j.socscimed.2022.115186
- Jul 3, 2022
- Social Science & Medicine
Equity in the use of physician services in Canada's universal health system: A longitudinal analysis of older adults
- Research Article
47
- 10.1186/1471-2458-11-642
- Aug 11, 2011
- BMC Public Health
BackgroundWhile there is considerable theoretical and empirical evidence on how job stress affects physical and mental health, few studies have examined the association between job related stress and health care utilization. Using data from the Canadian National Population Health Survey from 2000 to 2008, this paper examines the association between stressful working conditions, as measured by the job strain model, and the utilization of health care services.MethodsA zero inflated negative binomial regression is used to examine the excess health care utilization due to job strain. Separate regressions are estimated for both males and females since studies have shown gender differences in health care utilization.ResultsEstimates for the whole population show that high or medium job strain has a positive and statistically significant association with the number of visits to both a general practitioner (GP) and a specialist (SP). On average, the number of GP visits is up to 26% more (IRR = 1.26, 95% CI = 1.19-1.31) for individuals with high strain jobs compared to those in the low job strain category. Similarly, SP visits are up to 27% more (IRR = 1.27, 95% CI = 1.14-142) for the high strain category. Results are quantitatively similar for males and females, save for medium strain. In general, findings are robust to the inclusion of workplace social support, health status, provincial and occupational-fixed effects.ConclusionJob strain may be positively associated with the utilization of health care services. This suggests that improving psychosocial working conditions and educating workers on stress-coping mechanisms could be beneficial for the physical and mental health of workers.
- Research Article
- 10.1136/bmjopen-2025-110111
- May 26, 2026
- BMJ Open
ObjectivesTo examine the association between navigational health literacy (HL), defined as the skills required to effectively navigate healthcare systems, access services and make informed decisions and healthcare utilisation among French adults with and without chronic health conditions.DesignCross-sectional online survey.SettingNational survey conducted in metropolitan France as part of the Health Literacy Survey (HLS19) in 2020 and 2021.ParticipantsA total of 2 003 individuals were included: 1103 without chronic condition and 900 with at least one chronic condition.Outcomes measuresNumber of general practitioner (GP) and specialist visits in the previous 12 monthsResultsThe chronic condition group reported more frequent GP (4.3 vs 2.1/year) and specialist (2.8 vs 1.1/year) visits than the no chronic condition group. A high navigational HL was significantly associated with fewer GP (p=0.016) and specialist visits (p<0.001) only in the latter group. Other significant variables were age, gender, financial difficulties, self-reported health status and activity limitations. Younger persons and men reported fewer visits while those with poorer health and activity limitations reported more visits.ConclusionsHigh navigational HL was associated with less healthcare utilisation in individuals with no chronic condition. Among the chronic condition group, this aspect seemed less influential, likely due to greater healthcare system familiarity and structured care. Our findings highlight the importance of strengthening HL navigation skills early to improve healthcare use.
- Research Article
8
- 10.1080/13607863.2020.1742659
- Mar 19, 2020
- Aging & Mental Health
Objectives The aim of this study was to clarify the link between self-perceptions of ageing and the number of general practitioner (GP) visits, as well as frequent GP visits, longitudinally. Methods In this study, longitudinal data with n = 7,062 observations from 2014 (wave 5) to 2017 (wave 6) were taken from the German Ageing Survey (representative sample of middle aged and older individuals residing in private households). The five-item Attitudes Toward Own Ageing subscale of the Philadelphia Geriatric Center Morale Scale (PGCMS) was used to quantify self-perceptions of ageing. The frequency of GP visits in the past 12 months served as outcome measure (first model: measured continuously; second model: top 10% were defined as frequent attenders). To exploit the features of panel data, and to mitigate the problem of unobserved heterogeneity, fixed effects regressions were used. Results Adjusting for predisposing characteristics, enabling resources and need-factors, regressions showed that an increase in self-perceptions of ageing was associated with decreases in the number of GP visits (IRR= .83 (95% CI: .77-.91)), and a decreased likelihood of becoming a frequent attender (OR= .44 (95% CI: .29-.66)). Conclusions Using data from a longitudinal study and exploiting the longitudinal data structure, the current study adds to our current knowledge by demonstrating that self-perceptions of ageing contribute to the frequency of GP visits as well as frequent attendance. Since self-perceptions of ageing are modifiable, this may help to manage health care use.
- Research Article
14
- 10.1186/1472-6963-12-440
- Dec 1, 2012
- BMC Health Services Research
BackgroundThe evidence on the agreement between self-reported health resource use and administrative records is mixed and no gold standard exists. The objective of this study was to assess self-reported general practitioner (GP) and specialist doctor visits, as well as medication use via telephone interview against national insurance administrative data for colorectal cancer survivors.MethodsIn a sample of 76 adults recently diagnosed with colorectal cancer, data was abstracted from telephone survey items on GP visits, specialist visits and medication use over the previous six months and compared with data on the same individuals from administrative data. Intraclass correlation coefficients (ICC) were used to assess the reliability of frequency of visits and kappa statistics were derived for four broad categories of medicines used for gastrointestinal conditions, cardiovascular disease, psychological conditions and chronic obstructive pulmonary disease. Logistic regression was undertaken to assess factors associated with agreement (yes/no) between the two data sources for doctors’ visits.ResultsGood agreement was found for GP visits (ICC 0.62, 95%CI: 0.38, 0.86) and specialist visits (ICC 0.73, 95%CI: 0.56, 0.91) across the two data sources. When costs were assigned to frequencies, mean costs for the two methods were not significantly different over six months. Over-reporting was more common among men and participants with frequent doctor encounters. Large discrepancies between self-reports and administration records were found for broad types of medications used (44% agreement, kappa 0.13).ConclusionSelf-reported frequency of doctor’s visits using telephone interviews may be a reasonable substitute for administratively recorded data however, medication use by self-report appears to be unreliable. Administrative records are preferable to self-report for health service use in colorectal cancer survivors with high and complex service needs.
- Research Article
- 10.1007/s00464-025-12047-y
- Oct 1, 2025
- Surgical endoscopy
Bariatric surgery is considered the most effective treatment for obesity resulting in long-term weight loss and comorbidity resolution. Prior studies have examined the effect of socioeconomic status (SES) and urbanicity on weight loss and short-term outcomes. However, there is little data on the impact of SES and urbanicity on long-term healthcare utilization following bariatric surgery. The objective of this population-based study is to compare healthcare utilization in the years following bariatric surgery based on income quintile and urbanicity. All patients enrolled in the Centre for Metabolic and Bariatric Surgery (CMBS) who underwent laparoscopic gastric bypass or sleeve gastrectomy between 2013 and 2019 in Manitoba were included. Demographic information and healthcare utilization information were obtained from the Manitoba Population Research Data Repository, which is housed at the Manitoba Centre for Health Policy (MCHP). Income quintiles and area of living were determined using postal code of residence. Healthcare encounters measured included hospitalizations, general practitioner visits, specialist visits, CT scans, upper endoscopy, and number of outpatient prescription dispensations. All encounters were measured at 3 and 5years before and after the time of bariatric surgery. 1184 patients were included in this review, 478 living in a rural setting and 706 in an urban setting. In the 5years preceding bariatric surgery, there were no differences in the rates of polypharmacy, imaging, or endoscopy use between income quintiles among the rural population, while lower income quintiles experienced higher rates of hospitalization (p< 0.001) and GP visits (p< 0.001). At 5years after bariatric surgery, only GP visits (higher among lower income, p< 0.001) and specialist visits (higher among higher income, p< 0.001) were different within the rural population. Among the urban population, in the 5years preceding bariatric surgery lower income was associated with increased rates of polypharmacy (p = 0.001), imaging use (p = 0.004), and GP visits (p< 0.001). At 5years after bariatric surgery, lower income in the urban population was associated with increased rates of polypharmacy (p< 0.001), imaging use (p< 0.001), and GP visits (p< 0.001) along with higher rates of upper endoscopy (p< 0.001) and hospitalization (p = 0.02). Low-income patients living in an urban setting have the highest rates of healthcare utilization at 5years following bariatric surgery. These results are suggestive of a disparity in long-term outcomes based on SES and urbanicity. Future studies are needed to determine the underlying reasons for the increased healthcare utilization among urban, low-income patients and strategies to address them.
- Research Article
5
- 10.1186/s12913-021-07160-2
- Oct 19, 2021
- BMC Health Services Research
BackgroundResearchers often use survey data to study the effect of health and social variables on physician use, but how self-reported physician use compares to administrative data, the gold standard, in particular within the context of multimorbidity and functional limitations remains unclear. We examine whether multimorbidity and functional limitations are related to agreement between self-reported and administrative data for physician use.MethodsCross-sectional data from 52,854 Ontario participants of the Canadian Community Health Survey linked to administrative data were used to assess agreement on physician use. The number of general practitioner (GP) and specialist visits in the previous year was assessed using both data sources; multimorbidity and functional limitation were from self-report.ResultsFewer participants self-reported GP visits (84.8%) compared to administrative data (89.1%), but more self-reported specialist visits (69.2% vs. 64.9%). Sensitivity was higher for GP visits (≥90% for all multimorbidity levels) compared to specialist visits (approximately 75% for 0 to 90% for 4+ chronic conditions). Specificity started higher for GP than specialist visits but decreased more swiftly with multimorbidity level; in both cases, specificity levels fell below 50%. Functional limitations, age and sex did not impact the patterns of sensitivity and specificity seen across level of multimorbidity.ConclusionsCountries around the world collect health surveys to inform health policy and planning, but the extent to which these are linked with administrative, or similar, data are limited. Our study illustrates the potential for misclassification of physician use in self-report data and the need for sensitivity analyses or other corrections.
- Research Article
- 10.1186/s12889-025-25005-z
- Nov 4, 2025
- BMC Public Health
BackgroundInfluenza and pneumococcal vaccination coverage in older adults fall below the target of 80%. Being an immigrant may be associated with lower coverage of both vaccinations, but limited efforts have been made in the Canadian context to explore such disparities. Therefore, we examined the association between immigrant status and coverage of influenza and pneumococcal vaccinations among older adults as well as the relative importance of immigrant status in predicting coverage of both vaccinations.MethodsWe conducted a cross-sectional secondary analysis of the Canadian Longitudinal Study on Aging data. We descriptively analyzed coverage of both vaccinations by immigrant status and used Poisson regression models with robust standard errors to estimate the associations of immigrant status and other key equity stratifiers with vaccination. Importance of various determinants, including immigrant status, in predicting both vaccinations were assessed using random forest algorithms.ResultsImmigrant participants reported lower coverage of influenza vaccination in the past 12 months (63.8% [95% CI: 60.9–66.7%] vs. 66.9% [95% CI: 65.5–68.3%]) and pneumococcal vaccination ever (48.7% [95% CI: 45.6–51.8%] vs. 55.8% [95% CI: 54.3–57.3%]). Prevalence of influenza and pneumococcal vaccinations were both lower among immigrant participants compared to non-immigrant participants. Immigrant status was among the 10 most important predictors of pneumococcal vaccination, but among the less important predictors of influenza vaccination.ConclusionsOverall, we found disparities in influenza and pneumococcal vaccination by immigrant status among older adults in Canada. Further studies on vaccination coverage and decision-making among marginalized communities, including immigrants, are warranted to equitably improve vaccine uptake.Supplementary InformationThe online version contains supplementary material available at 10.1186/s12889-025-25005-z.
- Research Article
5
- 10.5812/jhealthscope.88589
- Dec 23, 2019
- Health Scope
Background: Equitable health care utilization is a pillar of the Universal Health Coverage (UHC) and is also a concern to policymakers. Measuring and quantifying the inequalities are essential in assessing the progress toward achieving the UHC goals. Several studies have focused on overall measures of unfair inequality in health care utilization. The overall approaches to outpatient and inpatient services are not representative of the differences in health care usage in public and private sectors in a mixed healthcare system, like Iran. A few studies have assessed inequality measures for general practitioners (GPs), specialists (SPs), and hospital admission services in different sectors, separately. Objectives: This study aimed at measuring health care utilization inequalities in outpatient and inpatient health services in public and private sectors in Iran. Methods: In this study, national representative data derived from the utilization of health services survey (UHSS) in 2014 was used. The concentration curve (CC) and concentration index (CI) were applied to assess inequalities in health care utilization services, including the number of GP visits, SP visits, and admission in hospitals. We used ADePT software to produce a nonlinear estimation of CI for these count variables. The indirect standardization method was used to standardize the services for differences in needs by age and gender. The inequality in health care utilization was examined in both public and private sectors, separately. Results: Based on the results, public and private outpatient settings, except for the private GP visits, followed a pro-poor pattern. Inpatient admission in the public sector had a pro-poor model, but it showed a pro-rich pattern in the private sector. GP visits in the private sector changed in favor of the poorer people and SP visits in the public sector changed toward a pro-rich pattern after standardization for differences in needs. CI for family physician (FP) and GP visits in public and private sectors, and also SP visits in public and private sectors was -0.089, -0.086, -0.010, 0.025, and -0.018, respectively. CI for the inpatient admission in public and private sectors was -0.126 and 0.157, respectively. GP, SP and hospital services utilization showed a pro-poor pattern. Conclusions: The results of this study showed that most of the health care utilization followed a pro-poor model in the mixed health care system in Iran. SP visits in the public sector changed toward a pro-rich pattern after standardization for differences in needs. Although public outpatient services need more attention to maintain their pro-poor distribution, SP visits in the public sector should be more considered to follow a pro-poor pattern. Health policymakers are recommended to take measures to eliminate barriers to access this service. This may lead to reduce a gap between the poor and rich people in the utilization of the health care and moving toward the UHC.
- Research Article
10
- 10.1186/s12913-018-3109-7
- Jun 5, 2018
- BMC Health Services Research
BackgroundResidence in public housing, a subsidized and managed government program, may affect health and healthcare utilization. We compared healthcare use in the year before individuals moved into public housing with usage during their first year of tenancy. We also described trends in use.MethodsWe used linked population-based administrative data housed in the Population Research Data Repository at the Manitoba Centre for Health Policy. The cohort consisted of individuals who moved into public housing in 2009 and 2010. We counted the number of hospitalizations, general practitioner (GP) visits, specialist visits, emergency department visits, and prescriptions drugs dispensed in the twelve 30-day intervals (i.e., months) immediately preceding and following the public housing move-in date. Generalized linear models with generalized estimating equations tested for a period (pre/post-move-in) by month interaction. Odds ratios (ORs), incident rate ratios (IRRs), and means are reported along with 95% confidence intervals (95% CIs).ResultsThe cohort included 1942 individuals; the majority were female (73.4%) who lived in low income areas and received government assistance (68.1%). On average, the cohort had more than four health conditions. Over the 24 30-day intervals, the percentage of the cohort that visited a GP, specialist, and an emergency department ranged between 37.0% and 43.0%, 10.0% and 14.0%, and 6.0% and 10.0%, respectively, while the percentage of the cohort hospitalized ranged from 1.0% to 5.0%. Generally, these percentages were highest in the few months before the move-in date and lowest in the few months after the move-in date. The period by month interaction was statistically significant for hospitalizations, GP visits, and prescription drug use. The average change in the odds, rate, or mean was smaller in the post-move-in period than in the pre-move-in period.ConclusionsUse of some healthcare services declined after people moved into public housing; however, the decrease was only observed in the first few months and utilization rebounded. Knowledge of healthcare trends before individuals move in are informative for ensuring the appropriate supports are available to new public housing residents. Further study is needed to determine if decreased healthcare utilization following a move is attributable to decreased access.
- Research Article
7
- 10.1080/13696998.2017.1345747
- Jul 4, 2017
- Journal of Medical Economics
Aims: Methods for integrating external costs into clinical databases are not well-characterized. The purpose of this research was to describe and implement methods for estimating the cost of hospitalizations, prescriptions, and general practitioner and specialist visits used to manage hyperlipidemia patients experiencing cardiovascular (CV) events in the United Kingdom (UK).Methods: This study was a retrospective cohort study using the Clinical Practice Research Datalink and Hospital Episode Statistics data. Costs were incorporated based on reference costs from the National Health Service, and labor costs from the Personal Social Services Research Unit. The study population included patients seen by general practitioners in the UK from 2006–2012. Patients ≥18 years were selected at the time of their first CV-related hospitalization defined as myocardial infarction, ischemic stroke, heart failure, transient ischemic attack, unstable angina, or revascularization. To be included, patients must have received ≥2 lipid-lowering therapies. Outcome measures included healthcare utilization and direct medical costs for hospitalizations, medications, general practitioner visits, and specialist visits during the 6-month acute period, starting with the CV hospitalization, and during the subsequent 30-month long-term period.Results: There were 24,093 patients with a CV hospitalization included in the cohort. This study identified and costed 69,240 hospitalizations, 673,069 GP visits, 32,942 specialist visits, and 2,572,792 prescriptions, representing 855 unique drug and dose combinations. The mean acute period and mean annualized long-term period costs (2014£) were £4,060 and £1,433 for hospitalizations, £377 and £518 for GP visits, £59 and £103 for specialist visits, and £98 and £209 for medications.Conclusions: Hospital costs represent the largest portion of acute and long-term costs in this population. Detailed costing using utilization data is feasible and representative of UK clinical practice, but is labor intensive. The availability of a standardized coding system in the UK drug costing data would greatly facilitate drug costing.
- Research Article
18
- 10.3390/ijerph19042258
- Feb 16, 2022
- International Journal of Environmental Research and Public Health
Background: The social representation of restricted health care use during the COVID-19 pandemic has not been evaluated properly yet in Hungary. Objective: Our study aimed to quantify the effect of COVID-19 pandemic measures on general practitioner (GP) visits, specialist care, hospitalization, and cost-related prescription nonredemption (CRPNR) among adults, and to identify the social strata susceptible to the pandemic effect. Methods: This cross-sectional study was based on nationally representative data of 6611 (Nprepandemic = 5603 and Npandemic = 1008) adults. Multivariable logistic regression models were applied to determine the sociodemographic and clinical factors influencing health care use by odds ratios (ORs) along with the corresponding 95% confidence intervals (CI). To identify the social strata susceptible to the pandemic effect, the interaction of the time of data collection with the level of education, marital status, and Roma ethnicity, was tested and described by iORs. Results: While the CRPNR did not change, the frequency of GP visits, specialist care, and hospitalization rates was remarkably reduced by 22.2%, 26.4%, and 6.7%, respectively, during the pandemic. Roma proved to be not specifically affected by the pandemic in any studied aspect, and the pandemic restructuring of health care impacted the social subgroups evenly with respect to hospital care. However, the pandemic effect was weaker among primary educated adults (iORGP visits, high-school vs. primary-education = 0.434; 95% CI 0.243–0.776, ORspecialist visit, high-school vs. primary-education = 0.598; 95% CI 0.364–0.985), and stronger among married adults (iORGP visit, widowed vs. married = 2.284; 95% CI 1.043–4.998, iORspecialist visit, widowed vs. married = 1.915; 95% CI 1.157–3.168), on the frequency of GP visits and specialist visits. The prepandemic CRPNR inequality by the level of education was increased (iORhigh-school vs. primary-education = 0.236; 95% CI 0.075–0.743). Conclusion: Primary educated and widowed adults did not follow the general trend, and their prepandemic health care use was not reduced during the pandemic. This shows that although the management of pandemic health care use restrictions was implemented by not increasing social inequity, the drug availability for primary educated individuals could require more support.
- Research Article
5
- 10.5770/cgj.17.83
- Mar 5, 2013
- Canadian Geriatrics Journal
BackgroundThis study aimed to determine the baseline demographics, health status, and drug use profiles of current and former substance-using older adults in Vancouver’s Downtown Eastside.MethodsData were derived from two U.S. National Institutes of Health-funded cohort studies of current and former illegal drug users in Vancouver’s Downtown Eastside. We used logistic regression of cross-sectional data obtained between June and November 2008 to calculate odds ratios and identify factors that were more commonly associated with cohort members being older adults (greater than or equal to age 50).Results214 subjects (25%) were greater than or equal to age 50 upon study enrollment. Females (Adjusted Odds Ratio [AOR]: 0.50; 95% CI: 0.34–0.75) and individuals who reported Aboriginal ancestry (AOR: 0.49; 95% CI: 0.33–0.72) were less likely to be in the older cohort. Individuals with higher income (AOR: 2.07; 95% CI: 1.16–3.68 per $1,000), and those with a regular place to stay were more likely to be in older cohort (AOR: 3.39; 95% CI: 1.90–6.06). Older participants accessed family physicians more frequently (OR: 1.47; 95% CI: 1.01 – 2.16) and were more likely to be actively taking (OR: 3.34; 95% CI 1.71–6.55) or have taken (OR 3.21; 95% CI 1.58–6.53) HIV antiretroviral therapy. There were no differences between groups in regard to injection drug use status or daily alcohol intake.ConclusionsOlder current and former illegal drug users in a major inner city Canadian centre have different demographic, health-care, and drug utilization profiles. Further studies in this population are warranted.