Abstract
The positive ion fast atom bombardment (FAB) mass spectral fragmentations of N-diisopropyloxyphosphinyl and N-dibutyloxyphosphinyl di- or tripeptides were carefully investigated. Results showed that the intense peaks involving base peaks were only the N-phosphoryl fragment ions while the C-terminal series ions and other ions derived from glycerol matrix were greatly suppressed. Successive McLafferty-type rearrangements to eliminate alkene were observed for protonated molecular ions and all N-phosphoryl fragment ions formed. These merits make it possible to use phosphoryl as better N-protected groups than others in the FAB mass spectrometric sequence analysis of peptides.
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