Fractional microneedling radiofrequency in striae alba: Do growth factors add value?

Abstract

Various treatment modalities have been applied to treat striae alba (SA) with low satisfaction rate. Fractional microneedling radiofrequency (FMR) provides deep dermal coagulation, thereby inducing collagen synthesis and tissue tightening. The addition of platelet-derived lyophilized growth factors may add to the effect of FMR. To evaluate and compare the efficacy and safety of FMR alone or combined with lyophilized growth factors in the treatment of SA. In this left-right comparative study, 25 patients suffering from SA on the abdomen received four sessions of FMR with lyophilized growth factors on one side and with saline (as placebo) on the other side at 4weeks interval. Photographic and biopsy documentation of the progress of the SA was carried out before the start of the treatment and 4weeks after the last session. Calculation of the width of SA before treatment and after 4 sessions was done by Adobe Photoshop CS6. There was a significant improvement in SA width after treatment in both the lyophilized growth factors (P=<.0001) and placebo sides (P=<.0001), the lyophilized growth factors being superior (P=.002). Patient satisfaction was more on the lyophilized growth factors (LGF) side (P=.034). Erythema and hyperpigmentation were less on the lyophilized growth factors side. Histopathologically, both showed improvement with no difference between LGF and placebo (epidermal thickness (P=.456), collagen content (P=.297), elastin content (P=.239)). The combination of FMR and lyophilized growth factors improves SA outcome.