Abstract
Purpose: to study the effect of low-intensity fractal light stimulation on the sensitivity in the visual field in patients with suspected glaucoma (SG) and primary open-angle glaucoma (POAG). Material and Methods. The study involved 146 people, including 98 patients of the main group (No. 1) and 49 people from the control group “placebo”-therapy (No. 2). Standard automatic perimetry was performed (SITA-Standard, Humphrey, CarlZeissMeditec, 24-2). The dynamics of the perimetry indices MD and PSD were evaluated before and after the course of a ten 10-minute session of fractal phototherapy or after a 10-day course of relaxation consisting in watching a particular training video twice a day. The maximum brightness of the flashes on the cornea during phototherapy was 10–12 lux, the fractal dimension of the optical signal was D = 1.4. Results. A two-week course of low-intensity stimulation with fractal optical signals reliably improved the MD reflected the common defect in the visual field, in all patients with SG and POAG. The expositions to videos with a relaxation program did not have a statistically significant effect on MD and PSD indices. The pronounced effect of fractal stimulation revealed in eyes with POAG III (a reduction of MD on average by 4.39 dB) suggests that even in advanced stages of glaucoma in the general population of retinal ganglion cells there is a significant percentage of cells that are still at the plastic stage of reversible functional changes and can respond positively to therapy. The results substantiate the feasibility of application neuroprotective therapy to patients with any stage of glaucoma, including the advanced stage. Conclusion. In this study, we first used the technology of fractal optical stimulation for the treatment of glaucoma. The first evidence of the neuroprotective effect of fractal phototherapy for POAG at different stages has been obtained. Fractal stimulation can be considered as a new non-pharmacological (physiotherapeutic) approach to neuroprotective therapy, whose potential and mechanisms need to be studied in future studies.
Highlights
Результаты экспериментальных исследований у жи‐ вотных показывают, что ухудшение ретроградной под‐ держки гангли‐ озных клеток (ГК) трофическими факторами может вносить значительный вклад в гибель ГК сетчатки, наблюдаемую при глаукомной оптической нейропатии [9, 10]
The dynamics of the perimetry indices MD and PSD were evaluated before and after the course of a ten 10-minute session of fractal phototherapy or after a 10-day course of relaxation consisting in watching a particular training video twice a day
A two-week course of low-intensity stimulation with fractal optical signals reliably improved the MD reflected the common defect in the visual field, in all patients with suspected glaucoma (SG) and primary open-angle glaucoma (POAG)
Summary
Целью работы явилось изучение влияния низкоинтенсивной фрактальной светостимуляции на чувствительность в поле зрения пациентов с подозрением на глаукому (ПГ) и с первичной открытоугольной глаукомой (ПОУГ). Двухнедельный курс низкоинтенсивной стимуляции фрактальными оптическими сигналами достоверно улучшал показатели MD, отражающие средний дефект в поле зрения, у всех пациентов с ПГ и ПОУГ. Результаты говорят о целесообразности проведения нейропротекторной терапии больным с любой стадией глаукомы, включая развитую стадию. В данном исследовании мы впервые использовали технологию фрактальной оптической стимуляции для терапии глаукомы. Фрактальная стимуляция может рассматриваться как новый нефармакологический, а физиотерапевтический подход к нейропротекторной терапии, чей потенциал и механизмы требуют дальнейшего изучения. Для цитирования: Зуева М.В., Ковалевская М.А., Донкарева О.В., Каранкевич А.И., Цапенко И.В., Таранов А.А., Антонян В.Б. Прозрачность финансовой деятельности: Никто из авторов не имеет финансовой заинтересованности в представленных материалах или методах
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
