FP23-TU-05 Coagulation factor gene polymorphisms in puerperal cerebral venous thrombosis

Abstract

Purpose: Puerperal cerebral venous thrombosis (PCVT) is a common cause of stroke in young women in India, where it is 10–12 times more common than in the West. The etiology of PCVT is not yet clear. Various thrombophilic gene polymorphisms have been reported to be associated with venous thrombosis in Caucasians. Published literature on their role in the etiology of PCVT is scarce. Hence, our aim was to evaluate the role of common single nucleotide thrombophilic gene polymorphisms such as prothrombin G20210>A, factor V Leiden G1691>A, factor V A4070>G and factor VII R353>Q as risk factors for PCVT. Methods: After approval by the NIMHANS Human Ethics committee, we investigated 100 female patients with a confirmed diagnosis of PCVT and 102 age-matched clinically normal women with no postnatal complications. Restriction length fragment polymorphism (RFLP) technique was used for identifying the presence or absence of the polymorphisms. Results: Factor V Leiden (OR=0.50, 95%CI = 0.09–2.79, p = 0.683), Factor V A4070G (OR=1.17, 95%CI = 0.49–2.75, p = 0.567) and factor VII R353Q (OR=1.55, 95%CI = 0.89–2.70, p = 0.243) polymorphisms were not significantly associated with PCVT. Moreover, coinheritance of these polymorphisms did not confer an increased risk for PCVT (OR=1.17, 95%CI = 0.53–2.61, p = 0.696). Prothrombin G202010A mutation was found to be absent in our population. Conclusion: We conclude that factor V Leiden, factor V A4070G and factor VII R353Q polymorphisms, though present in the Indian population, are not significantly associated with increased risk for PCVT in Indian women.