Abstract
Biomolecules have the advantage of high performance parallel computing and large information capacity. The use of biochemical circuits to solve computational problems has been studied by many researchers. In this paper, we use DNA strand displacement technology to construct complex molecular circuits as logic gates. The experimental process is demonstrated by a series of strand displacement reactions, and the feasibility of the design is verified by the strand displacement simulation platform Visual DSD. The key feature of this logic gate design is that when two inputs of the same signal are controlled, the remaining two different input signals implement AND and OR function to determine the output. Based on this feature, a four-input multi-layer logic circuit is designed and implemented. The calculation mode of the other three inputs AND and OR combinations is implemented by controlling each logic gate input.
Highlights
DNA is an excellent engineering material for biochemical circuits [1], [2]
DNA strand displacement cascade [21]–[23] reaction realizes the dynamic connection between adjacent logic modules, which makes it possible for researchers to construct large-scale complex logic circuits [24], [25] at nanoscale
Four different calculation modes of the circuit can be switched by controlling each logic gate input
Summary
DNA is an excellent engineering material for biochemical circuits [1], [2]. DNA is an ideal candidate for molecular programming that facilitates both in vivo and in vitro applications because of its biological and physical properties [3]–[5]. DNA strand displacement cascade [21]–[23] reaction realizes the dynamic connection between adjacent logic modules, which makes it possible for researchers to construct large-scale complex logic circuits [24], [25] at nanoscale. It gets important research significance in the fields of building logic gate operation model, biochemical logic circuit and neural network, DNA nano robot, DNA reflection network [26]–[28]. A four-input logic gate was constructed based on the basic principle of DNA strand displacement reaction. The simulation software DSD is used to simulate and verify the reliability of the design
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